Tyrosine Phosphoprotein Phosphatases (Protein Profile) - Couverture souple

Goldstein, Barry J.

Couverture souple

ISBN 10 : 0198502478 ISBN 13 : 9780198502470

Editeur : Oxford University Press, USA, 1998

Synopsis

Book by Goldstein Barry J

A propos du livre

Présentation de l'éditeur :

Over the past 15 years researchers have made enormous gains in understanding the various aspects of tyrosine phosphoprotein phosphatases (PTPases), with particularly important insights into their molecular biology, biochemistry, and role in cellular physiology. This new edition of Tyrosine Phosphoprotein Phosphatases provides a practical and accessible guide to this major family of proteins. Topics discussed include the sequence, structure, and biochemical properties of PTPases, regulation of PTPase expression, substrate preferences and catalytic mechanisms, physiology, covalent modification, modification by chemical agents and proteolysis, and interactions with other proteins, peptides, and macromolecules. Featuring comprehensive coverage of the subject, including an extensive bibliography, this volume will provide an important resource for researchers and graduate students in molecular biology and biochemistry.

Présentation de l'éditeur :

Tyrosine phosphoprotein phosphatases (PTPases) are found ubiquitously in cytosolic and particulate fractions of cells. They are unique in terms of their substrate sensitivity, neutral pH optimum, resistance to EDTA, and inhibition by low concentrations of zinc or vandanate. PTPases exert both positive and negative effects on a number of metabolic and signal transduction pathways. This volume explores the sequence, structure, and biochemical properties of PTPases, regulation of PTPase expression, substrate preferences and catalytic mechanisms, physiology, covalent modification, modification by chemical agents and proteolysis, and interactions with other proteins, peptides, and macromolecules. There is an extensive bibliography to assist the reader in further research.

À propos de cette édition

• Éditeur: Oxford University Press, USA
• Date d'édition: 1998
• ISBN 10: 0198502478
• ISBN 13: 9780198502470
• Reliure: Broché
• Numéro d'édition: 2
• Nombre de pages: 270