Virus Dynamics: The Mathematical Foundations of Immunology and Virology - Couverture rigide

Nowak, Martin A.; May, Robert M.

Couverture rigide

ISBN 10 : 0198504187 ISBN 13 : 9780198504184

Editeur : Oxford University Press, 2000

Synopsis

Book by Nowak Martin A May Robert

A propos du livre

Présentation de l'éditeur :

We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study.

Revue de presse :

... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host (Nature)

À propos de cette édition

• Éditeur: Oxford University Press
• Date d'édition: 2000
• ISBN 10: 0198504187
• ISBN 13: 9780198504184
• Reliure: Relié
• Nombre de pages: 250