Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

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9780470569061: Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

With its clear, straightforward presentation, this text enables youto grasp all the fundamental concepts of pharmacokinetics andpharmacodynamics. This will allow you to understand the time courseof drug response and dosing regimen design. Clinical models forconcentration and response are described and built from the basicconcepts presented in earlier chapters. Your understanding of thematerial will be enhanced by guided computer exercises conducted ona companion website. Simulations will allow you to visualize drugbehavior, experiment with different dosing regimens, and observethe influence of patient characteristics and model parameters. Thismakes the book ideal for self-study. By including clinical models of agonism, indirect drug effects,tolerance, signal transduction, and disease progression, authorSara Rosenbaum has created a work that stands out amongintroductory-level textbooks in this area.You'll find severalfeatures throughout the text to help you better understand andapply key concepts: * Three fictitious drugs are used throughout the text toprogressively illustrate the development and application ofpharmacokinetic and pharmacodynamic principles * Exercises at the end of each chapter reinforce the concepts andprovide the opportunity to perform and solve common dosingproblems * Detailed instructions let you create custom Excel worksheets toperform simple pharmacokinetic analyses Because this is an introductory textbook, the material ispresented as simply as possible. As a result, you'll find it easyto gain an accurate, working knowledge of all the core principles,apply them to optimize dosing regimens, and evaluate the clinicalpharmacokinetic and pharmacodynamic literature.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Quatrième de couverture :

Interactive Computer Simulations Enable You to Quickly Learn andApply New Skills

With its clear, straightforward presentation, this text enablesyou to grasp all the fundamental concepts of pharmacokinetics andpharmacodynamics. This will allow you to understand the time courseof drug response and dosing regimen design. Clinical models forconcentration and response are described and built from the basicconcepts presented in earlier chapters. Your understanding of thematerial will be enhanced by guided computer exercises conducted ona companion website. Simulations will allow you to visualize drugbehavior, experiment with different dosing regimens, and observethe influence of patient characteristics and model parameters. Thismakes the book ideal for self–study.

By including clinical models of agonism, indirect drug effects,tolerance, signal transduction, and disease progression, authorSara Rosenbaum has created a work that stands out amongintroductory–level textbooks in this area.You′ll find severalfeatures throughout the text to help you better understand andapply key concepts:

  • Three fictitious drugs are used throughout the text toprogressively illustrate the development and application ofpharmacokinetic and pharmacodynamic principles

  • Exercises at the end of each chapter reinforce the concepts andprovide the opportunity to perform and solve common dosingproblems

  • Detailed instructions let you create custom Excel worksheets toperform simple pharmacokinetic analyses

Because this is an introductory textbook, the material ispresented as simply as possible. As a result, you′ll find it easyto gain an accurate, working knowledge of all the core principles,apply them to optimize dosing regimens, and evaluate the clinicalpharmacokinetic and pharmacodynamic literature.

Revue de presse :

I could recommend Rosenbaum s book for pharmacologystudents because it is written from  a perspective of drugaction . . . Overall, this is a well–written introduction to PK/PDthat may fill a small niche in a well–served market.  (British Toxicology Society Newsletter, 1 June 2012)

"In summary, I believe that this book is successful in what it setsout to do. For those readers who are interested in getting to gripswith the basics of the time course of onset, offset and extent ofdrug effects then this is the book for you. I am certainlyrecommending this book for my graduate students." (British Journalof Clinical Pharmacology, 2011)

"A readable font size, good quality paper and a stout bindingmake this an excellent offering ... This is an ideal textbook forthose starting out on the pharmacokinetic trail and also for use asa reference book for those who delve occasionally into thissubject." (International Society for the Study ofXenobiotics, 1 April 2012)

"In short, this is a thorough and well–designed presentation anddevelopment of key concepts in pharmacokinetics andpharmacodynamics. It is a very useful textbook, and one that Iwould be comfortable using in both medical and graduate teaching."(Doody′s, 21 October 2011)

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

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