Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

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9780470569061: Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

With its clear, straightforward presentation, this text enables youto grasp all the fundamental concepts of pharmacokinetics andpharmacodynamics. This will allow you to understand the time courseof drug response and dosing regimen design. Clinical models forconcentration and response are described and built from the basicconcepts presented in earlier chapters. Your understanding of thematerial will be enhanced by guided computer exercises conducted ona companion website. Simulations will allow you to visualize drugbehavior, experiment with different dosing regimens, and observethe influence of patient characteristics and model parameters. Thismakes the book ideal for self-study. By including clinical models of agonism, indirect drug effects,tolerance, signal transduction, and disease progression, authorSara Rosenbaum has created a work that stands out amongintroductory-level textbooks in this area.You'll find severalfeatures throughout the text to help you better understand andapply key concepts: * Three fictitious drugs are used throughout the text toprogressively illustrate the development and application ofpharmacokinetic and pharmacodynamic principles * Exercises at the end of each chapter reinforce the concepts andprovide the opportunity to perform and solve common dosingproblems * Detailed instructions let you create custom Excel worksheets toperform simple pharmacokinetic analyses Because this is an introductory textbook, the material ispresented as simply as possible. As a result, you'll find it easyto gain an accurate, working knowledge of all the core principles,apply them to optimize dosing regimens, and evaluate the clinicalpharmacokinetic and pharmacodynamic literature.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Quatrième de couverture :

Interactive Computer Simulations Enable You to Quickly Learn andApply New Skills

With its clear, straightforward presentation, this text enablesyou to grasp all the fundamental concepts of pharmacokinetics andpharmacodynamics. This will allow you to understand the time courseof drug response and dosing regimen design. Clinical models forconcentration and response are described and built from the basicconcepts presented in earlier chapters. Your understanding of thematerial will be enhanced by guided computer exercises conducted ona companion website. Simulations will allow you to visualize drugbehavior, experiment with different dosing regimens, and observethe influence of patient characteristics and model parameters. Thismakes the book ideal for self–study.

By including clinical models of agonism, indirect drug effects,tolerance, signal transduction, and disease progression, authorSara Rosenbaum has created a work that stands out amongintroductory–level textbooks in this area.You′ll find severalfeatures throughout the text to help you better understand andapply key concepts:

  • Three fictitious drugs are used throughout the text toprogressively illustrate the development and application ofpharmacokinetic and pharmacodynamic principles

  • Exercises at the end of each chapter reinforce the concepts andprovide the opportunity to perform and solve common dosingproblems

  • Detailed instructions let you create custom Excel worksheets toperform simple pharmacokinetic analyses

Because this is an introductory textbook, the material ispresented as simply as possible. As a result, you′ll find it easyto gain an accurate, working knowledge of all the core principles,apply them to optimize dosing regimens, and evaluate the clinicalpharmacokinetic and pharmacodynamic literature.

Revue de presse :

I could recommend Rosenbaum s book for pharmacologystudents because it is written from  a perspective of drugaction . . . Overall, this is a well–written introduction to PK/PDthat may fill a small niche in a well–served market.  (British Toxicology Society Newsletter, 1 June 2012)

"In summary, I believe that this book is successful in what it setsout to do. For those readers who are interested in getting to gripswith the basics of the time course of onset, offset and extent ofdrug effects then this is the book for you. I am certainlyrecommending this book for my graduate students." (British Journalof Clinical Pharmacology, 2011)

"A readable font size, good quality paper and a stout bindingmake this an excellent offering ... This is an ideal textbook forthose starting out on the pharmacokinetic trail and also for use asa reference book for those who delve occasionally into thissubject." (International Society for the Study ofXenobiotics, 1 April 2012)

"In short, this is a thorough and well–designed presentation anddevelopment of key concepts in pharmacokinetics andpharmacodynamics. It is a very useful textbook, and one that Iwould be comfortable using in both medical and graduate teaching."(Doody′s, 21 October 2011)

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

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Sara E. Rosenbaum
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Description du livre Wiley, 2011. État : New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: "Unlike other basic textbooks that cover only pharmacokinetics, the author has done justice to the title of the book by covering pharmacodynamics. Pharmacodynamics is covered in greater depth than other books in the same category. What makes the book to stand out is that the author has nicely blended the concepts of receptor theory from classical pharmacology with the modern science of PK/PD. The book truly helps readers to understand the science of pharmacokinetics and drug action. The Excel-based simulation exercises incorporated into the text helps the reader to put his/her learning into practice, albeit in a virtual environment. The book is strongly recommended for use in undergraduate studies of PK/PD, and by those in drug research interested in having a basic understanding of the science of PK/PD." - Ene Ette , PhD, Anoixis Corporation "Sara Rosenbaum's book is a thoroughly modern approach to pharmacokinetics and pharmacodynamics. It is well written and well thought out - a blend of pharmacokinetic-pharmacodynamic theory and modeling/analysis concepts. The pharmacodynamic models are up to date with recent advances in the field, such as tolerance, indirect, and basic disease progression models, being presented. The web page simulations were fun to play around with allowing the user to change the model parameters and see how the results change. Rather than being a dry subject with just endless equations, the connection between the web-based simulations and the book allows the reader to be engaged and understand the subject with greater ease." - Peter L. Bonate , PhD, author of Pharmacokinetic-Pharmacodynamic Modeling and Simulation. N° de réf. du libraire ABE_book_new_0470569069

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Description du livre Wiley. État : New. 0470569069 This is an International Edition. Brand New, Paperback, Delivery within 6-14 business days, Similar Contents as U.S Edition, ISBN and Cover design may differ, printed in Black & White. Choose Expedited shipping for delivery within 3-8 business days. We do not ship to PO Box, APO , FPO Address. In some instances, subjects such as Management, Accounting, Finance may have different end chapter case studies and exercises. International Edition Textbooks may bear a label "Not for sale in the U.S. or Canada" and "Content may different from U.S. Edition" - printed only to discourage U.S. students from obtaining an affordable copy. The U.S. Supreme Court has asserted your right to purchase international editions, and ruled on this issue. Access code/CD is not provided with these editions , unless specified. We may ship the books from multiple warehouses across the globe, including India depending upon the availability of inventory storage. Customer satisfaction guaranteed. N° de réf. du libraire OM9780470569061

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Description du livre John Wiley and Sons Ltd, United States, 2011. Mixed media product. État : New. 252 x 178 mm. Language: English . Brand New Book. With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You ll find several features throughout the text to help you better understand and apply key concepts: * Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles * Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems * Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you ll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature. N° de réf. du libraire AAC9780470569061

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