Cardiotoxicity of Non-Cardiovascular Drugs

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9780470772744: Cardiotoxicity of Non-Cardiovascular Drugs

Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use.

In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include:

  •  metabolic targets of cardiotoxicity
  • regulatory aspects
  • translating molecular mechanisms into clinical trials
  • structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs
  • cardiovascular toxicity of antitumor drugs
  • cardiovascular toxicities of non-steroidal anti-inflammatory drugs
  • cardiovascular toxicities of antiretroviral therapies

Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

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Some drugs which are not aimed at treating heart diseases have nevertheless been found to have profound effects on the cardiovascular system. Cardiotoxicity is one of the major untoward effects of drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. In recent years a number of non-cardiac blockbuster drugs have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been halted prior to marketing or required labelling changes that significantly restricted their use.

In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Emphasis is also paid to the preclinical screening of drug cardiotoxicity.

Topics include:

  • metabolic targets of cardiotoxicity
  • regulatory aspects
  • cellular mechanisms, molecular targets and structure-activity relationships in arrhythmias by antihistamines, psychoactive drugs and antimicrobial agents
  • cardiovascular toxicity of antitumor drugs
  • cardiovascular toxicities of non-steroidal anti-inflammatory drugs
  • cardiovascular toxicities of antiretroviral therapies

Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development and surveillance. It will find a place on the bookshelves of basic and clinical researchers, regulators, and students interested in oncology, cardiology, pharmacology, medicinal chemistry and drug development.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

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Giorgio Minotti
Edité par John Wiley and Sons Ltd, United States (2010)
ISBN 10 : 0470772743 ISBN 13 : 9780470772744
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Description du livre John Wiley and Sons Ltd, United States, 2010. Hardback. État : New. New.. Language: English . Brand New Book. Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: * metabolic targets of cardiotoxicity * regulatory aspects * translating molecular mechanisms into clinical trials * structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs * cardiovascular toxicity of antitumor drugs * cardiovascular toxicities of non-steroidal anti-inflammatory drugs * cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease. N° de réf. du libraire AAH9780470772744

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Giorgio Minotti
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ISBN 10 : 0470772743 ISBN 13 : 9780470772744
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Giorgio Minotti
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Giorgio Minotti
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Description du livre John Wiley and Sons Ltd, United States, 2010. Hardback. État : New. New.. Language: English . Brand New Book. Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: * metabolic targets of cardiotoxicity * regulatory aspects * translating molecular mechanisms into clinical trials * structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs * cardiovascular toxicity of antitumor drugs * cardiovascular toxicities of non-steroidal anti-inflammatory drugs * cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease. N° de réf. du libraire AAH9780470772744

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Giorgio Minotti (University Campus Bio-Medico of Rome, Italy)
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Giorgio Minotti
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Giorgio Minotti
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Minotti, Giorgio
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Giorgio Minotti
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ISBN 10 : 0470772743 ISBN 13 : 9780470772744
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Description du livre John Wiley and Sons Ltd, United States, 2010. Hardback. État : New. New.. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: * metabolic targets of cardiotoxicity * regulatory aspects * translating molecular mechanisms into clinical trials * structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs * cardiovascular toxicity of antitumor drugs * cardiovascular toxicities of non-steroidal anti-inflammatory drugs * cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease. N° de réf. du libraire BZV9780470772744

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GIORGIO MINOTTI
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