Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped - and who continue to shape - the field today.
Key features include:
Moment of Discovery
Each chapter opens with a description of a significant breakthrough in molecular biology relevant to that chapter, as told by the scientist who made the discovery. They make this a relevant, living subject to students.
- Joe DeRisi, on his discovery of the SARS virus (Chapter 8)
- Melissa Jurica, on her discovery of the first EM structures of spliceosomes (Chapter 16)
- Bonnie Bassler, on her discovery of interspecies quorum sensing (Chapter 20)
How We Know
This end-of-chapter section combines fascinating stories of research and researchers with actual experimental data for students to analyze, often drawing on the work of the scientist featured in the chapter's 'Moment of Discovery.' This ensures the material covered in the book is always shown to be relevant to how scientists really work.
A short section at the end of each chapter describes important areas still open to discovery, showing students that even well-covered subjects such as nucleic acid structure and DNA replication are far from fully explored. This emphasises the evolving nature of the subject and show students how their work could have impact in the future.
These brief paragraphs clearly lay out for student some fundamental principles often glossed over by instructors and textbooks because they are so well understood by professionals. They are helpful to students, who could otherwise be thrown by such assumptions.
Throughout each chapter, special features focus on fascinating topics that enhance student understanding of the concepts:
· Medicine looks at diseases that arise from defects in biochemical pathways, or examples of how concepts learned in molecular biology have contributed to drug therapies or other treatments.
· Technology focuses on cutting-edge molecular biology methods that students will likely be hearing about or even using in the future.
· Evolution reveals the role of molecular biology research in understanding key biological processes and the connections between organisms.
· A Closer Look highlights a wide variety of additional, intriguing topics.
· Encourages practice and critical thinking
These give students the opportunity to think about and work with the chapter's key ideas. Each problem set concludes with a Data Analysis Problem, giving students the crucial experience of interpreting real data from actual research (most often the work described in the 'How We Know' section). Solutions to the problems can be found at the end of the book.
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A highly engaging and memorable textbook that strikes a balance between explaining fundamental concepts and an experimental emphasisAbout the Author :
MICHAEL M. COX was born in Wilmington, Delaware. After graduating from the University of Delaware, USA, in 1974, Cox went to Brandeis University to do his doctoral work with William P. Jencks, and then to Stanford in 1979 for postdoctoral study with I. Robert Lehman. He moved to the University of Wisconsin-Madison, USA in 1983, and became a full professor of biochemistry in 1992. His research focuses on recombinational DNA repair processes. In addition to the work on this text, Cox is a co-author of four editions of Lehninger Principles of Biochemistry. He has received awards for both his teaching and his research, including the 1989 Eli Lilly Award in Biological Chemistry, and two major teaching awards from the University of Wisconsin, USA, and the University of Wisconsin System. His hobbies include travel, gardening, wine collecting, and assisting in the design of laboratory buildings.
JENNIFER A. DOUDNA grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley, USA, and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in Biochemistry from Pomona
College, USA, and her Ph.D. from Harvard University, USA, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado, USA, as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. She is a member of the Scientific Advisory Board of the David and Lucile Packard Foundation and a Trustee of Pomona College. Doudna is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is also a Fellow of the American Association for the Advancement of Science.
MICHAEL O'DONNELL received his Ph.D. at the University of Michigan, USA, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O'Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University, USA in 1996. O'Donnell is a member of the National Academy of Sciences.
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