Cyclopropanes in Organic Synthesis - Couverture rigide

Kulinkovich, Oleg G.

Couverture rigide

ISBN 10 : 1118057430 ISBN 13 : 9781118057438

Editeur : John Wiley & Sons Inc, 2015

A propos du livre

Quatrième de couverture :

Used in total synthesis of natural products and other complex molecules, cyclopropanes can be conveniently prepared with different approaches and used as intermediates to make target–directed organic transformations  more efficient. The synthetic potential of cyclopropane derivatives is often overlooked but is nonetheless universal and could be more efficient than standard approaches.

This book provides a comprehensive review of cyclopropanes their properties, preparation, synthesis, and applications. It includes comprehensive references and synopses of review articles on  experimental data and theoretical interpretations of the geometry of cyclopropanes and also discusses typical transformations of substituted cyclopropanes, derivatives, and intermediates, with emphasis on highly selective transformations of easily available cyclopropane precursors. The author provides a detailed description of successful applications of cyclopropane approaches in target–oriented syntheses classified by the class of the target structures and  transformation type, and mode of the activation of the cyclopropane ring toward its cleavage.

Overall, the book stresses universality, experimental efficiency, and strategic importance of synthetic methodologies based on an efficient preparation of cyclopropane derivatives and their involvement in smooth ring opening or fragmentation reactions with inexpensive reagents. A valuable guide for practicing chemists, this book offers key features that include:

          A resource to help readers better understand cyclopropane applications for the efficient realization of synthetically important organic transformations and popular experimental procedures
          New developments and up–to–date information that will lead to original methodologies for complex organic synthesis
          Focus on the synthetic potential of cyclopropane applications, as well on their planning by retrosynthetic analysis

Présentation de l'éditeur :

This is a practical guidebook about cyclopropanes that thoroughly surveys derivatives and transformations, synthetic methods, and experimental efficiency as a gateway for further research and development in the field.

    Provides comprehensive lists and synthetically–oriented synopses of cyclopropane chemistry review references along with publication data on applications in the syntheses of natural and related biologically active compounds
    Acts as a resource to help readers better understand cyclopropane applications for the efficient realization of synthetically important organic transformations and popular experimental procedures
    Includes new developments and up–to–date information that will lead to original methodologies for complex organic synthesis
    Stresses universality, flexibility, and experimental efficiency of a strategy based on preparing cyclopropane derivatives and performing ring cleavage reactions with inexpensive reagents
    Focuses on the synthetic potential of cyclopropane applications, for example  the synthesis of natural compounds and other target–oriented syntheses via cyclopropane intermediaries, as well on their planning by retrosynthetic analysis

À propos de cette édition

• Éditeur: John Wiley & Sons Inc
• Date d'édition: 2015
• ISBN 10: 1118057430
• ISBN 13: 9781118057438
• Reliure: Relié
• Nombre de pages: 432