Interpretation of MS-MS Mass Spectra of Drugs and Pesticides - Couverture rigide

Niessen, Wilfried M. A.; Correa C., Ricardo A.

Couverture rigide

ISBN 10 : 1118500180 ISBN 13 : 9781118500187

Editeur : John Wiley & Sons Inc, 2017

A propos du livre

Présentation de l'éditeur

Mass spectrometry (MS) is an indispensable tool in structure elucidation and quantitative analysis of a wide variety of compound classes, such as drugs and pesticides. For this purpose, MS is mostly used in combination with either gas or liquid chromatography (GC-MS or LC-MS). In compound identification by LC-MS, extensive knowledge is needed on the fragmentation of even-electron ions in tandem mass spectrometry (MS-MS). Interpretation of MS-MS Mass Spectra of Drugs and Pesticides details all of the relevant information on the fragmentation of drugs and pesticides, while proposing general fragmentation rules. Information about the fragmentation of drugs and pesticides in the scientific literature is both very scattered and rather incomplete. This book provides comprehensive information on fragmentation pathways of the various chemical compound classes. Whenever available or useful, fragmentation in both positive-ion and negative-ion modes is discussed and compared. Interpretation of MS-MS spectra of important classes of compounds including drugs for cardiovascular diseases and hypertension, psychotropic or psychoactive compounds, drugs related to the gastrointestinal tract, antimicrobial compounds, and other classes of drugs, such as steroids, drugs of abuse, as well as pesticides and herbicides ; A general discussion on the fragmentation of even-electron ions in both positive-ion and negative-ion modes ; Important information on how to interpret spectra so that fragments that are not contained in a particular database can be correctly identified ; Discussion on interpretation strategies in different application areas of small-molecule LC-MS ; Introduction to MS-MS technology, concepts, and terminology used in mass spectral analysis ; As there is no comprehensive book on the interpretation of MS-MS mass spectra of small organic molecules, this book would of great interest to many scientists looking to interpret mass spectra of such compounds.

Biographie de l'auteur

Wilfried M A Niessen is an analytical chemist with 34 years of experience as a researcher and project manager in the field of principles, instrumentation, and applications of liquid chromatography-mass spectrometry. As a consultant for hyphen MassSpec, he works all over Europe and beyond, having provided over 400 courses in more than 15 countries, as well as many consultancy projects. He was extraordinary professor in bioanalytical mass spectrometry at the VU University Amsterdam. He is the (co)author of more than 210 publications in the field of LC-MS, over 40 book chapters, 6 books, and a guest editor for six special volumes on mass spectrometry topics published by the Journal of Chromatography A. Ricardo A Correa C is an organic chemist who has been involved with mass spectrometry for 25 years. He runs Trans-Laboratory, a chemical analysis service provider, offering course cycles around Europe on analytical chemistry where GC-MS and LC-MS play a central role. He has developed applications that have been presented in scientific meetings in Belgium and The Netherlands, as well as coordinated the setup of analytical chemistry laboratories overseas. He is the co-author of publications for reputed chemistry journals such as the Journal of the American Chemical Society, the Journal of Organic Chemistry, and the Journal of Chromatography A.

À propos de cette édition

• Éditeur: John Wiley & Sons Inc
• Date d'édition: 2017
• ISBN 10: 1118500180
• ISBN 13: 9781118500187
• Reliure: Relié
• Nombre de pages: 416