Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Section I. Compartments and Pathways 1. Overview of Intracellular Compartments and Trafficking Pathways Andrei A. Tokarev, Aixa Alfonso and Nava Segev 2. How We Study Protein Transport Mary L. Preuss, Peggy Weidman an. N� de r�f. du vendeur 4197461

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Trafficking Inside Cells : Pathways; Mechanisms and Regulation

Aixa Alfonso

Edit� par Springer (2012)

ISBN 10 : 1461424658 ISBN 13 : 9781461424659

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Description du livre Etat : New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. N� de r�f. du vendeur ria9781461424659_lsuk

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Trafficking Inside Cells : Pathways, Mechanisms and Regulation

Nava Segev

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ISBN 10 : 1461424658 ISBN 13 : 9781461424659

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Description du livre Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The SecretoryPathway The transport ofproteins and lipids from their site ofsynthesis at the endoplasmic reticu lum (ER) to the cellsurface ismediated by the secretory pathway and isan essential process in eukaryotic organisms. A great variety ofmolecules are extruded from cellsby the action ofthe secretory pathway, including extracellular matrix components that provide the foundation for constructing tissuesand organs. Moreover, this pathway playsa major role in the biogenesisof the plasma membraneand itsexpansion before celldivision. Therefore, withoutsecretion there would be no cells,tissuesor organs, and so it issafeto saythat we oweourvery existence to the secretory pathway. To understand the process ofsecretion we must learn about the organelles that compose the secretory pathway; the ER and Golgi apparatus, and the transport vesicles these or ganelles produce. The membrane ofthese organelles is primarily synthesized and assembled at the ER but with contributions from mitochondria (phosphatidylethanolamine) and the Golgi apparatus (sphingolipids). Newly synthesized proteins destined for secretion gain en try into the secretory pathway by translocation across the ER membrane. This translocation apparatus also integrates proteins into the membrane and establishes their topology with respect to the lipid bilayer (seeChapter 7). Many secretory proteins are covalently modified with oligosaccharides to produce glycoproteins, a biosynthetic process initiated in the ER and continued in the Golgi apparatus. Once proteins are properly folded and modified in the ER, they are allowed to leave and are ushered into COPlI-coated carrier vesiclesforming at specific exit sites (see Chapters 1 and 8). N� de r�f. du vendeur 9781461424659

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