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Description du livre Etat : New. N° de réf. du vendeur 46975668-n
Description du livre Paperback. Etat : new. Paperback. In this postgenome era, the large number of mouse mutations available is revolutionizing biomedical research. Large-scale mutagenesis projects have resulted in the modification of thousands of mouse genes and, more recently, with CRISPR-Cas gene editing, generation of custom mutations is easier than ever. The interpretation of mutant phenotypes is critically important for understanding how changes in the genome result in changes in the phenotype. Complex phenotypes resulting from gene manipulation or spontaneous mutation, however, provide a huge analytic challenge. Where does one start with the analysis? How does one dissect the phenotype and begin to understand the molecular and developmental consequences of the genotype? How does one make the best use of the valuable resource that you have developed? Mouse Phenotypes: A Handbook of Mutation Analysis, Second Edition, provides a road map for such analysis. Advice and practical guidance are provided, starting with the planning stages of gene targeting, CRISPR-Cas gene editing, or mutagenesis experiments, through the complete analysis of complex phenotypes, including tips on breeding strategies, studying dominant mutations, and characterizing a mutant mouse with no apparent phenotypic abnormalities. A systematic approach to the analysis, complemented with simple protocols, will help users make a comprehensive assessment of a particular phenotype resulting from a mutation and determine the timing and likely causes of specific developmental failures. Investigators using the laboratory mouse in genetic studies designed to understand mammalian biology will benefit from the authors' experience and advice in analyzing mutant phenotypes. This book provides a road map for such analysis. Advice and practical guidance are provided, starting with the planning stages of gene targeting, CRISPR-Cas gene editing, or mutagenesis experiments, through the complete analysis of complex phenotypes, including tips on breeding strategies, studying dominant mutations, and characterizing a mutant mouse with no apparent phenotypic abnormalities. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. N° de réf. du vendeur 9781621824183
Description du livre Paperback. Etat : Brand New. 2nd lab edition. 306 pages. 8.90x10.30x1.00 inches. In Stock. N° de réf. du vendeur x-1621824187
Description du livre Etat : New. N° de réf. du vendeur 46975668-n
Description du livre paperback. Etat : New. Language: ENG. N° de réf. du vendeur 9781621824183
Description du livre Etat : New. N° de réf. du vendeur 26397662884
Description du livre Etat : New. N° de réf. du vendeur 398747003
Description du livre Etat : New. N° de réf. du vendeur I-9781621824183