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Description du livre Hardcover. Etat : new. N° de réf. du vendeur 9781627031004
Description du livre Etat : New. N° de réf. du vendeur ABLIING23Mar2811580170013
Description du livre Etat : New. N° de réf. du vendeur 18485620-n
Description du livre Etat : New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. N° de réf. du vendeur ria9781627031004_lsuk
Description du livre Gebunden. Etat : New. N° de réf. du vendeur 4267512
Description du livre Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring's well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next. 200 pp. Englisch. N° de réf. du vendeur 9781627031004
Description du livre Buch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring's well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next. N° de réf. du vendeur 9781627031004
Description du livre Etat : New. N° de réf. du vendeur 18485620-n
Description du livre Hardcover. Etat : Brand New. 1st edition. 189 pages. 9.00x6.25x0.50 inches. In Stock. N° de réf. du vendeur x-1627031006
Description du livre Etat : New. This book shows how the mitochondrial genome is transmitted, segregated and inherited. Opens by describing mtDNA mutations and deletions and showing how these impact the offspring's well-being, covers mtDNA transmission and discusses transmittal and adaptation. Editor(s): St. John, Justin. Series: Stem Cell Biology and Regenerative Medicine. Num Pages: 190 pages, 5 black & white tables, biography. BIC Classification: PSAK; PSF. Category: (P) Professional & Vocational. Dimension: 243 x 161 x 18. Weight in Grams: 440. . 2012. 2013th Edition. hardcover. . . . . N° de réf. du vendeur V9781627031004