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Toll-like Receptors in Health and Disease: 276 (Handbook of Experimental Pharmacology) - Couverture rigide
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- ÉditeurSpringer-Verlag GmbH
- Date d'édition2022
- ISBN 10 3031065115
- ISBN 13 9783031065118
- ReliureTapa dura
- Numéro d'édition1
- Nombre de pages314
- ÉditeurKumar Vijay
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Toll-like Receptors in Health and Disease
Edité par
Springer International Publishing Jun 2022
(2022)
ISBN 10 : 3031065115
ISBN 13 : 9783031065118
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Description du livre Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans.The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development. 324 pp. Englisch. N° de réf. du vendeur 9783031065118
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Toll-like Receptors in Health and Disease
Edité par
Springer, Berlin|Springer International Publishing|Springer
(2022)
ISBN 10 : 3031065115
ISBN 13 : 9783031065118
Neuf
Couverture rigide
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Description du livre Gebunden. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopoly. N° de réf. du vendeur 584144073
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Image fournie par le vendeur
Toll-like Receptors in Health and Disease
Edité par
Springer International Publishing
(2022)
ISBN 10 : 3031065115
ISBN 13 : 9783031065118
Neuf
Couverture rigide
Quantité disponible : 1
Vendeur :
Evaluation vendeur
Description du livre Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans.The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development. N° de réf. du vendeur 9783031065118
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Autre devise