Microwaves in Organic and Medicinal Chemistry, Volume 25 (Methods and Principles in Medicinal Chemistry)

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9783527312108: Microwaves in Organic and Medicinal Chemistry, Volume 25 (Methods and Principles in Medicinal Chemistry)

The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

From the Back Cover :

The complete guide to microwave synthesis in medicinal chemistry synthesis -- while also containing a "crash-course" for newcomers.

Compared to conventional heating methods, microwave irradiation causes less side-reactions and losses through decomposition and can be easily adapted to different chemical reaction conditions. Cheap and reliable, this method has been successfully used for a variety of chemical reactions, most notably in the synthesis of drugs and drug-like compounds.

In this handy reference, the authors focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists.

From the contents:

  • Introduction
  • Microwave theory
  • Equipment review
  • Microwave processing techniques
  • Getting started with microwave chemistry
  • Literature survey: general organic synthesis
  • Literature survey: combinatorial and high-throughput synthesis

The authors are all experts on the use of microwaves for drug synthesis and have ample teaching experience from courses held under the auspices of the American Chemical Society and the IUPAC. The result is an indispensable information source for organic and medicinal chemists, as well as those in industry and the pharmaceutical industry.

About the Author :

C. Oliver Kappe was born in Graz (Austria) and received his doctoral degree from the Karl-Franzens-University in Graz in 1992, working with Gert Kollenz on acylketenes. After postdoctoral research work with Curt Wentrup at the University of Queensland, Brisbane (Australia), and with Albert Padwa at Emory University, Atlanta (USA), he moved back to the University of Graz where he currently holds a position as associate Professor. In 2003 he spent a sabbatical at the Scripps Research Institute in La Jolla (USA) with K. Barry Sharpless. His research focuses on microwave-enhanced synthesis, combinatorial chemistry, multicomponent reactions, and biologically active heterocycles.

Alexander Stadler was born in Bruck and der Mur (Austria) and studied Chemistry at the University of Graz. He then obtained his doctoral degree for studies on microwave-accelerated reactions in solution and on solid phase in the group of C. Oliver Kappe. After postdoctoral research work on microwave-assisted transition metal-catalyzed coupling reactions in the group of Mats Larhed at the University of Uppsala (Sweden) he joined Anton Paar GmbH in Graz in 2004 as product specialist for microwave synthesis.

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Kappe, C. Oliver, Stadler, Alexander
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ISBN 10 : 3527312102 ISBN 13 : 9783527312108
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C. Oliver Kappe; Alexander Stadler; Series Editor-Raimund Mannhold; Series Editor-Hugo Kubinyi; Series Editor-Gerd Folkers
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Description du livre WILEY-VCH. État : Gebraucht. Gebraucht - Sehr gut Mängelexemplar mit leichten Lagerspuren, Sofortversand - The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.< Deutsch. N° de réf. du libraire INF1000066500

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Description du livre WILEY-VCH. État : Gebraucht. Gebraucht - Sehr gut Mängelexemplar mit leichten Lagerspuren, Sofortversand - The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.< Deutsch. N° de réf. du libraire INF1000066474

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