Nuclear Receptors As Drug Targets (39) - Couverture rigide

9783527318728: Nuclear Receptors As Drug Targets (39)

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ISBN 10 : 3527318720 ISBN 13 : 9783527318728

Editeur : Blackwell Verlag GmbH, 2008

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Quatri�me de couverture :

Nuclear receptors are the site of action for some of the most widely used medications, namely oral contraceptives and related drugs derived from steroid hormones. Recent research has uncovered their pivotal role in a range of human diseases, including diabetes and metabolic syndrome, triggering a new wave of drug discovery efforts focused on this class of molecular targets.
Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone–derived drugs, this handbook systematically treats the drug development aspects of all human nuclear receptors, including such recently characterized receptors as PPAR, FXR and LXR, and modern tools for nuclear receptor research.
With its contributions from authors working at leading pharmaceutical companies around the world providing examples and real–life data from their own experience, this is an invaluable reference for medicinal chemists, biochemists, molecular biologists, pharmacologists and those working in the pharmaceutical industry.

Revue de presse :

"With increasing importance attributed to this area, the text is a welcome review of the current field.... The quality of the text is good with very readable chapters and many useful original literature references. The book will be clearly valuable for both academic and industrial groups engaged in drug discovery." ( Journal of Medicinal Chemistry, March 2009)

"This is an excellent book for scientists interested in adding or expanding expertise in nuclear receptor drug discovery to their skill set. The chapters are timely, well referenced into the 2008 literature, and focused on the chemistry of successful and emerging therapeutic small molecules." (Journal of the American Chemical Society, March 10, 2009)

"The book is a good reference for medicinal chemists, pharmacologists and those working in the pharmaceutical industry." (RoSearch, December 2008)

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