Current Concepts in Autoimmunity and Chronic Inflammation - Couverture souple

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9783642067457: Current Concepts in Autoimmunity and Chronic Inflammation

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ISBN 10 : 364206745X ISBN 13 : 9783642067457

Editeur : Springer, 2010

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The ethiopathologies of autoimmune diseases are complex. A broad variety of cell types and gene products are involved. This book explores clinical and experimental evidence suggesting that the importance of an individual factor changes during the course of the disease. Factors and cell types that induce acute autoreactivity and initiate an autoimmune disease could be distinct from those that drive a chronic course of that disease.

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�diteur: Springer
Date d'�dition: 2010
Langue: anglais
ISBN 10: 364206745X
ISBN 13: 9783642067457
Reliure: Broch�
Num�ro d'�dition: 1
Nombre de pages: 296
�diteur: Radbruch Andreas, Lipsky Peter E.
Coordonn�es du fabricant: ProductSafety@springernature.com
ProductSafety@springernature.com

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Allemagne

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Current Concepts in Autoimmunity and Chronic Inflammation (eng)

Radbruch, Andreas

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Current Concepts in Autoimmunity and Chronic Inflammation

Radbruch, Andreas|Lipsky, Peter E.

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Discusses the complex ethiopathologies of autoimmune diseasesExplores the broad variety of cell types and genes involvedShows how initiating factors in autoimmune disease can possibly be distinct from those that drive the chro. N� de r�f. du vendeur 5045836

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Current Concepts in Autoimmunity and Chronic Inflammation

Peter E. Lipsky

Edit� par Springer Berlin Heidelberg Feb 2010, 2010

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of 'horror autotoxicus' is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality. 292 pp. Englisch. N� de r�f. du vendeur 9783642067457

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Current Concepts in Autoimmunity and Chronic Inflammation (Current Topics in Microbiology and Immunology, 305)

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Current Concepts in Autoimmunity and Chronic Inflammation

Peter E. Lipsky (u. a.)

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Current Concepts in Autoimmunity and Chronic Inflammation

Peter E. Lipsky

Edit� par Springer Berlin Heidelberg, Springer Feb 2010, 2010

ISBN 10 : 364206745X ISBN 13 : 9783642067457

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of �horror autotoxicus� is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch. N� de r�f. du vendeur 9783642067457

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Current Concepts in Autoimmunity and Chronic Inflammation

Peter E. Lipsky

Edit� par Springer Spektrum, 2010

ISBN 10 : 364206745X ISBN 13 : 9783642067457

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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of 'horror autotoxicus' is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality. N� de r�f. du vendeur 9783642067457

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