Description du livre Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Prokaryotic Toxins - Antitoxins gives the first overview of an exciting and rapidly expanding research field. Toxin - antitoxin (TA) genes were discovered on plasmids 30 years ago. Since then it has become evident that TA genes are highly abundant in bacterial and archaeal chromosomes. TA genes code for an antitoxin that combine with and neutralize a cognate toxin. When activated, the toxins inhibit protein synthesis and cell growth and thereby induce dormancy and multidrug tolerance (persistence). Remarkably, in some species, the TA gene families have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has '100 TA loci. The large expansion of TA genes by some organisms is a biological mystery. However, recent observations indicate that TA genes contribute cumulatively to the persistence of bacteria. This medically important phenomenon may thus for the first time become experimentally tractable at the molecular level. 376 pp. Englisch. N� de r�f. du vendeur 9783642332524

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Prokaryotic Toxin-Antitoxins

Gerdes, Kenn

Edit� par Springer Berlin Heidelberg (2012)

ISBN 10 : 3642332528 ISBN 13 : 9783642332524

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moluna
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Description du livre Etat : New. N� de r�f. du vendeur 5057207

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Prokaryotic Toxin-Antitoxins

Kenn Gerdes

Edit� par Springer Berlin Heidelberg (2012)

ISBN 10 : 3642332528 ISBN 13 : 9783642332524

Neuf Couverture rigide Quantit� disponible : 1

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AHA-BUCH GmbH
(Einbeck, Allemagne)

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Description du livre Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Prokaryotic Toxins - Antitoxins gives the first overview of an exciting and rapidly expanding research field. Toxin - antitoxin (TA) genes were discovered on plasmids 30 years ago. Since then it has become evident that TA genes are highly abundant in bacterial and archaeal chromosomes. TA genes code for an antitoxin that combine with and neutralize a cognate toxin. When activated, the toxins inhibit protein synthesis and cell growth and thereby induce dormancy and multidrug tolerance (persistence). Remarkably, in some species, the TA gene families have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has '100 TA loci. The large expansion of TA genes by some organisms is a biological mystery. However, recent observations indicate that TA genes contribute cumulatively to the persistence of bacteria. This medically important phenomenon may thus for the first time become experimentally tractable at the molecular level. N� de r�f. du vendeur 9783642332524

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