Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Renal transport and xenobiotic metabolism play an important role in the detoxication and excretion of potentially toxic xenobiotics. However, recent experimental evidence has demonstrated that renal xenobiotic metabolism and renal transport processes also play an important role in the nephrotoxicity of xenobiotics and xenobiotic metabolites. The high blood flow to the kidney combined with its ability to concentrate solutes may expose the kidney to high concentrations of xenobiotics and xenobiotics metabolites present in the systemic circulation. Recently, it has been demonstrated that xenobiotic metabolites formed in the liver and other organs may be targeted to the kidney by selective transport systems~ many xenobiotics require enzymatic transformation to proximate reactive metabolites to elicit their toxic and carcinogenic effects. The enzymatic formation of reactive metabolites is termed bioactivation. The bioactivation mechanisms for many nephrotoxicants have, at least in part, been elucidated in the past 15 years. Many ultimate toxicants formed in the kidney are electrophiles whose interaction with cellular macromolecules may cause a perturbation of normal cell function resulting in necrosis and/or cancer (Anders 1988). Electrophilic metabolites may bind to nucleophilic sites in cellular macromolecules~ the importance of covalent modification of protein and DNA in cell killing and in the induction of tumors is established (Miller and Miller 1981~ Nelson and Pearson 1990~ Hinson and Roberts 1992). The objective of this review is to summarize new information about renal transport, renal bioactivation and their relation to nephrotoxicity using two relevant example for the basic mechanisms outlined above. 456 pp. Englisch. N� de r�f. du vendeur 9783642646966

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 112,34

Autre devise

Ajouter au panier

Frais de port : EUR 23

De Allemagne vers Etats-Unis

Destinations, frais et d�lais

Image d'archives

Toxicology- From Cells to Man

Seiler, J�rg P.

Edit� par Springer (2011)

ISBN 10 : 3642646964 ISBN 13 : 9783642646966

Neuf Couverture souple Quantit� disponible : 4

Vendeur :

Books Puddle
(New York, NY, Etats-Unis)

Evaluation vendeur

Evaluation du vendeur :

Description du livre Etat : New. pp. 456. N� de r�f. du vendeur 2648021243

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 134,14

Autre devise

Ajouter au panier

Frais de port : EUR 3,69

Vers Etats-Unis

Destinations, frais et d�lais

Image fournie par le vendeur

Toxicology- From Cells to Man

Seiler, J�rg P.|Kroftova, Olga|Eybl, Vladislav

Edit� par Springer Berlin Heidelberg (2011)

ISBN 10 : 3642646964 ISBN 13 : 9783642646966

Neuf Couverture souple Quantit� disponible : > 20

impression � la demande

Vendeur :

moluna
(Greven, Allemagne)

Evaluation vendeur

Evaluation du vendeur :

Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Renal transport and xenobiotic metabolism play an important role in the detoxication and excretion of potentially toxic xenobiotics. However, recent experimental evidence has demonstrated that renal xenobiotic metabolism and renal transport processes also p. N� de r�f. du vendeur 5066911

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 92,27

Autre devise

Ajouter au panier

Frais de port : EUR 48,99

De Allemagne vers Etats-Unis

Destinations, frais et d�lais

Image fournie par le vendeur

Toxicology- From Cells to Man : Proceedings of the 1995 EUROTOX Congress Meeting Held in Prague, Czech Republic, August 27�l30, 1995

J�rg P. Seiler

Edit� par Springer Berlin Heidelberg (2011)

ISBN 10 : 3642646964 ISBN 13 : 9783642646966

Neuf Taschenbuch Quantit� disponible : 1

Vendeur :

AHA-BUCH GmbH
(Einbeck, Allemagne)

Evaluation vendeur

Evaluation du vendeur :

Description du livre Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Renal transport and xenobiotic metabolism play an important role in the detoxication and excretion of potentially toxic xenobiotics. However, recent experimental evidence has demonstrated that renal xenobiotic metabolism and renal transport processes also play an important role in the nephrotoxicity of xenobiotics and xenobiotic metabolites. The high blood flow to the kidney combined with its ability to concentrate solutes may expose the kidney to high concentrations of xenobiotics and xenobiotics metabolites present in the systemic circulation. Recently, it has been demonstrated that xenobiotic metabolites formed in the liver and other organs may be targeted to the kidney by selective transport systems~ many xenobiotics require enzymatic transformation to proximate reactive metabolites to elicit their toxic and carcinogenic effects. The enzymatic formation of reactive metabolites is termed bioactivation. The bioactivation mechanisms for many nephrotoxicants have, at least in part, been elucidated in the past 15 years. Many ultimate toxicants formed in the kidney are electrophiles whose interaction with cellular macromolecules may cause a perturbation of normal cell function resulting in necrosis and/or cancer (Anders 1988). Electrophilic metabolites may bind to nucleophilic sites in cellular macromolecules~ the importance of covalent modification of protein and DNA in cell killing and in the induction of tumors is established (Miller and Miller 1981~ Nelson and Pearson 1990~ Hinson and Roberts 1992). The objective of this review is to summarize new information about renal transport, renal bioactivation and their relation to nephrotoxicity using two relevant example for the basic mechanisms outlined above. N� de r�f. du vendeur 9783642646966

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 113,89

Autre devise

Ajouter au panier

Frais de port : EUR 32,99

De Allemagne vers Etats-Unis

Destinations, frais et d�lais

Image d'archives

Toxicology- From Cells to Man

. Ed(s): Seiler, Jurg P. (Riedtwil, Switzerland); Kroftova, Olga; Eybl, Vladislav

Edit� par Springer-Verlag Berlin and Heidelberg GmbH & Co. KG (2011)

ISBN 10 : 3642646964 ISBN 13 : 9783642646966

Neuf Couverture souple Quantit� disponible : 15

Vendeur :

Kennys Bookshop and Art Galleries Ltd.
(Galway, GY, Irlande)

Evaluation vendeur

Evaluation du vendeur :

Description du livre Etat : New. Editor(s): Seiler, Jurg P. (Riedtwil, Switzerland); Kroftova, Olga; Eybl, Vladislav. Series: Archives of Toxicology. Num Pages: 441 pages, 41 black & white tables, biography. BIC Classification: MJCM; MMG; PSB. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 23. Weight in Grams: 685. . 2011. Softcover reprint of the original 1st ed. 1996. Paperback. . . . . N� de r�f. du vendeur V9783642646966

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 140,29

Autre devise

Ajouter au panier

Frais de port : EUR 10,50

De Irlande vers Etats-Unis

Destinations, frais et d�lais

Image d'archives

Toxicology- From Cells to Man

Seiler, J�rg P.

Edit� par Springer (2011)

ISBN 10 : 3642646964 ISBN 13 : 9783642646966

Neuf Couverture souple Quantit� disponible : 4

impression � la demande

Vendeur :

Majestic Books
(Hounslow, Royaume-Uni)

Evaluation vendeur

Evaluation du vendeur :

Description du livre Etat : New. Print on Demand pp. 456 65 Figures, 49:B&W 6.14 x 9.21 in or 234 x 156 mm (Royal 8vo) Perfect Bound on White w/Gloss Lam. N� de r�f. du vendeur 44761380

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 146,44

Autre devise

Ajouter au panier

Frais de port : EUR 7,63

De Royaume-Uni vers Etats-Unis

Destinations, frais et d�lais

There are autres exemplaires de ce livre sont disponibles

Afficher tous les r�sultats pour ce livre

Articles li�s � Toxicology - From Cells to Man: Proceedings of the...

Toxicology - From Cells to Man: Proceedings of the 1995 EUROTOX Congress Meeting Held in Prague, Czech Republic, August 27-l30, 1995 - Couverture souple

Acheter neuf

Autres �ditions populaires du m�me titre

Edition pr�sent�e

Meilleurs r�sultats de recherche sur AbeBooks

There are autres exemplaires de ce livre sont disponibles