Motor neuron regeneration in the spinal cord of adult zebrafish: (HAMILTON, 1822) - Couverture souple

Reimer, Michell Mario

Couverture souple

ISBN 10 : 3838117069 ISBN 13 : 9783838117065

Editeur : Suedwestdeutscher Verlag fuer Hochschulschriften, 2010

A propos du livre

Présentation de l'éditeur :

Adult zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Using immunohistochemical markers and transgenic reporter fish for motor neurons, this study demonstrates that large differentiated motor neurons are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and are replaced. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the motor neuron progenitor/stem cells in the lesioned spinal cord. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that sonic hedgehog is an important regulator of motor neuron regeneration. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease.

Biographie de l'auteur :

Dr. Michell M. Reimer is a researcher at the University of Edinburgh, UK. His area of interest is the role of oligodendrocyte precursor cells (such as the ependymo-radial glial cells in zebrafish) and oligodendrocytes in disease, regeneration and ageing. He received his PhD from the University of Hamburg in 2008.

À propos de cette édition

• Éditeur: Suedwestdeutscher Verlag fuer Hochschulschriften
• Date d'édition: 2010
• ISBN 10: 3838117069
• ISBN 13: 9783838117065
• Reliure: Broché
• Nombre de pages: 100