Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Heterochromatin protein 1 (HP1) proteins are fundamental units of heterochromatin packaging.In mammals,there are three HP1 homologues termed HP1 (Cbx5),HP1 (Cbx1) and HP1 (Cbx3).HP1 is the best characterized isoform.Murine HP1 is essential for organismal survival.This study demonstrates that Cbx1+/- and Cbx1-/- MEFs escape senescence crisis that is associated with chromosomal aberrations.Telomeres of late passage Cbx1-/- MEFs are longer than WT controls. Introduction of Cbx1-/- mutation in cells expressing H-rasV12 oncogene did not result senescence bypass.K-rasV12 oncogene expression in Cbx1+/- mice resulted in increased malignant adenocarcinomas.These data indicate that HP1 acts as a tumour suppressor.Other experiments showed that binding of HP1 to histone H3(HH3) is resistant to high salt concentrations.ITC experiments confirmed that binding affinity of HP1 for HH3 was 4 times higher than for H3K9me3.The high affinity binding of HP1 to the HH3 is shown to be stronger than the affinity to H3K9me3.Loss of this interaction might result in the perinatal lethal phenotype seen in Cbx1-/- mice. 160 pp. Englisch. N� de r�f. du vendeur 9783838123196

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 79

Autre devise

Ajouter au panier

Frais de port : EUR 23

De Allemagne vers Etats-Unis

Destinations, frais et d�lais

Image d'archives

Heterochromatin Protein 1 HP1 It's role on genomic stability and cellular senescence

Billur, Mustafa

Edit� par Suedwestdeutscher Verlag fuer Hochschulschriften (2011)

ISBN 10 : 3838123190 ISBN 13 : 9783838123196

Neuf PAP Quantit� disponible : > 20

impression � la demande

Vendeur :

PBShop.store US
(Wood Dale, IL, Etats-Unis)

Evaluation vendeur

Evaluation du vendeur :

Description du livre PAP. Etat : New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. N� de r�f. du vendeur L0-9783838123196

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 106,91

Autre devise

Ajouter au panier

Frais de port : Gratuit

Vers Etats-Unis

Destinations, frais et d�lais

Image fournie par le vendeur

Heterochromatin Protein 1 (HP1 ) : It's role on genomic stability and cellular senescence

Mustafa Billur

Edit� par S�dwestdeutscher Verlag F�r Hochschulschriften (2011)

ISBN 10 : 3838123190 ISBN 13 : 9783838123196

Neuf Taschenbuch Quantit� disponible : 2

impression � la demande

Vendeur :

AHA-BUCH GmbH
(Einbeck, Allemagne)

Evaluation vendeur

Evaluation du vendeur :

Description du livre Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Heterochromatin protein 1 (HP1) proteins are fundamental units of heterochromatin packaging.In mammals,there are three HP1 homologues termed HP1 (Cbx5),HP1 (Cbx1) and HP1 (Cbx3).HP1 is the best characterized isoform.Murine HP1 is essential for organismal survival.This study demonstrates that Cbx1+/- and Cbx1-/- MEFs escape senescence crisis that is associated with chromosomal aberrations.Telomeres of late passage Cbx1-/- MEFs are longer than WT controls. Introduction of Cbx1-/- mutation in cells expressing H-rasV12 oncogene did not result senescence bypass.K-rasV12 oncogene expression in Cbx1+/- mice resulted in increased malignant adenocarcinomas.These data indicate that HP1 acts as a tumour suppressor.Other experiments showed that binding of HP1 to histone H3(HH3) is resistant to high salt concentrations.ITC experiments confirmed that binding affinity of HP1 for HH3 was 4 times higher than for H3K9me3.The high affinity binding of HP1 to the HH3 is shown to be stronger than the affinity to H3K9me3.Loss of this interaction might result in the perinatal lethal phenotype seen in Cbx1-/- mice. N� de r�f. du vendeur 9783838123196

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 79,95

Autre devise

Ajouter au panier

Frais de port : EUR 32,99

De Allemagne vers Etats-Unis

Destinations, frais et d�lais

Image d'archives

Heterochromatin Protein 1 HP1 It's role on genomic stability and cellular senescence

Billur, Mustafa

Edit� par Suedwestdeutscher Verlag fuer Hochschulschriften (2011)

ISBN 10 : 3838123190 ISBN 13 : 9783838123196

Neuf PAP Quantit� disponible : > 20

impression � la demande

Vendeur :

PBShop.store UK
(Fairford, GLOS, Royaume-Uni)

Evaluation vendeur

Evaluation du vendeur :

Description du livre PAP. Etat : New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. N� de r�f. du vendeur L0-9783838123196

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 86,68

Autre devise

Ajouter au panier

Frais de port : EUR 29,35

De Royaume-Uni vers Etats-Unis

Destinations, frais et d�lais

Image fournie par le vendeur

Heterochromatin Protein 1ss (HP1ss)

Billur, Mustafa

Edit� par S�dwestdeutscher Verlag f�r Hochschulschriften (2011)

ISBN 10 : 3838123190 ISBN 13 : 9783838123196

Neuf Couverture souple Quantit� disponible : > 20

impression � la demande

Vendeur :

moluna
(Greven, Allemagne)

Evaluation vendeur

Evaluation du vendeur :

Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Heterochromatin protein 1 (HP1) proteins are fundamental units of heterochromatin packaging.In mammals,there are three HP1 homologues termed HP1 (Cbx5),HP1 (Cbx1) and HP1 (Cbx3).HP1 is the best characterized isoform.Murine HP1 is essential for organismal su. N� de r�f. du vendeur 5406664

Plus d'informations sur ce vendeur | Contacter le vendeur

Acheter neuf

EUR 67,89

Autre devise

Ajouter au panier

Frais de port : EUR 48,99

De Allemagne vers Etats-Unis

Destinations, frais et d�lais

Articles li�s � Heterochromatin Protein 1? (HP1?): It's role on...

Heterochromatin Protein 1? (HP1?): It's role on genomic stability and cellular senescence - Couverture souple

Acheter neuf

Meilleurs r�sultats de recherche sur AbeBooks