Formulation and Evaluation of Buspirone Hydrochloride Buccal Films: Buspirone Hydrochloride Buccal Films

 
9783844315851: Formulation and Evaluation of Buspirone Hydrochloride Buccal Films: Buspirone Hydrochloride Buccal Films
Présentation de l'éditeur :

Buspirone Hydrochloride is used in the treatment of anxiety. It has a short half life and low oral bioavailability of 5%. Therefore, the purpose of this research was to develop unidirectional Bucco- adhesive films of Buspirone Hydrochloride by solvent casting technique using full factorial designs. HPMC K15M and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 was used as plasticizer and Sodium lauryl sulphate was used as permeation enhancer in different concentration. The physicochemical compatibility of the drug and the polymers was studied by FT-IR spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. In full factorial designs, total amount of polymer (X1) and percentage of HPMC K15M (X2) was kept as a independent variables. After wards, statistically optimization process was carried out and two optimized formulation (OF1 and OF2) was developed. The results of optimization formulation showed greater degree of % similarity with predicted values. Stability studies of two optimized formulations were carried out at room temperature as per ICH Q1C guidelines.

Biographie de l'auteur :

Dr. Upendra Nagaich is currently working as Asstt. Professor in BVM College of Pharmacy, Gwalior (M.P.) India. He is working as Editor of 'Journal of Advanced Pharmaceutical Technology & Research'(JAPTR). He has published several research papers in various journals. He is associated as Editorial Board Member of several journals.

Dr. Upendra Nagaich is currently working as Asstt. Professor in BVM College of Pharmacy, Gwalior (M.P.) India. He is working as Editor of 'Journal of Advanced Pharmaceutical Technology & Research'(JAPTR). He has published several research papers in various journals. He is associated as Editorial Board Member of several journals.

Dr. Upendra Nagaich is currently working as Asstt. Professor in BVM College of Pharmacy, Gwalior (M.P.) India. He is working as Editor of 'Journal of Advanced Pharmaceutical Technology & Research'(JAPTR). He has published several research papers in various journals. He is associated as Editorial Board Member of several journals.

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Roopa Karki; Upendra Nagaich; Vandana Chaudhary
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Roopa Karki; Upendra Nagaich; Vandana Chaudhary
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Description du livre LAP Lambert Acad. Publ. Mrz 2011, 2011. Taschenbuch. État : Neu. 220x150x9 mm. This item is printed on demand - Print on Demand Neuware - Buspirone Hydrochloride is used in the treatment of anxiety. It has a short half life and low oral bioavailability of 5%. Therefore, the purpose of this research was to develop unidirectional Bucco- adhesive films of Buspirone Hydrochloride by solvent casting technique using full factorial designs. HPMC K15M and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 was used as plasticizer and Sodium lauryl sulphate was used as permeation enhancer in different concentration. The physicochemical compatibility of the drug and the polymers was studied by FT-IR spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. In full factorial designs, total amount of polymer (X1) and percentage of HPMC K15M (X2) was kept as a independent variables. After wards, statistically optimization process was carried out and two optimized formulation (OF1 and OF2) was developed. The results of optimization formulation showed greater degree of % similarity with predicted values. Stability studies of two optimized formulations were carried out at room temperature as per ICH Q1C guidelines. 148 pp. Englisch. N° de réf. du libraire 9783844315851

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Roopa Karki; Upendra Nagaich; Vandana Chaudhary
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Description du livre LAP Lambert Academic Publishing, Germany, 2011. Paperback. État : New. 220 x 150 mm. Language: English . Brand New Book ***** Print on Demand *****.Buspirone Hydrochloride is used in the treatment of anxiety. It has a short half life and low oral bioavailability of 5 . Therefore, the purpose of this research was to develop unidirectional Bucco- adhesive films of Buspirone Hydrochloride by solvent casting technique using full factorial designs. HPMC K15M and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 was used as plasticizer and Sodium lauryl sulphate was used as permeation enhancer in different concentration. The physicochemical compatibility of the drug and the polymers was studied by FT-IR spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. In full factorial designs, total amount of polymer (X1) and percentage of HPMC K15M (X2) was kept as a independent variables. After wards, statistically optimization process was carried out and two optimized formulation (OF1 and OF2) was developed. The results of optimization formulation showed greater degree of similarity with predicted values. Stability studies of two optimized formulations were carried out at room temperature as per ICH Q1C guidelines. N° de réf. du libraire AAV9783844315851

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Roopa Karki; Upendra Nagaich; Vandana Chaudhary
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Description du livre LAP LAMBERT Academic Publishing. Paperback. État : New. Paperback. 148 pages. Dimensions: 8.7in. x 5.9in. x 0.3in.Buspirone Hydrochloride is used in the treatment of anxiety. It has a short half life and low oral bioavailability of 5. Therefore, the purpose of this research was to develop unidirectional Bucco- adhesive films of Buspirone Hydrochloride by solvent casting technique using full factorial designs. HPMC K15M and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 was used as plasticizer and Sodium lauryl sulphate was used as permeation enhancer in different concentration. The physicochemical compatibility of the drug and the polymers was studied by FT-IR spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. In full factorial designs, total amount of polymer (X1) and percentage of HPMC K15M (X2) was kept as a independent variables. After wards, statistically optimization process was carried out and two optimized formulation (OF1 and OF2) was developed. The results of optimization formulation showed greater degree of similarity with predicted values. Stability studies of two optimized formulations were carried out at room temperature as per ICH Q1C guidelines. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. N° de réf. du libraire 9783844315851

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