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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol: Using Model dependent and Independent Methods and Bioequivalence Study
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Présentation de l'éditeur :
Current study aimed at the development of a matrix type sustain release Diclofenac tablet, using hydrophilic HPMC and hydrophobic polymer Cetyl alcohol. It was found that hydrophilic Methocel K15 MCR® matrices based tablets showed zero order and hydrophobic cetyl alcohol matrices based tablets were followed first-order kinetics except formulation six (F6 showed zero order profile). The result of dissolution study indicated that formulations containing cetyl alcohol showed better dissolution properties as compared to formulations containing Methocel K15 MCR® in terms of similarity and difference factor. By comparing the dissolution profiles with Voltaren SR® tablet in terms of difference factors and similarity factors, it was revealed that the formulation F-4, F-5 and F-6 exhibited similar drug release profile as that of Voltaren SR® tablet which indicated that these formulations could be bioequivalent with Voltaren SR® tablet in vitro. The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCR® and cetyl alcohol in the form of matrix tablets with similar dissolution profile of patent product Voltaren SR®.
Biographie de l'auteur :
Md. Imamul Islam, MS in Pharmaceutical Science, Jahangirnagar University, Savar, Dhaka-1342,Researcher in the Protein Biochemistry Laboratory, Chosun University, South Korea.
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- ÉditeurLAP LAMBERT Academic Publishing
- Date d'édition2012
- ISBN 10 3844386297
- ISBN 13 9783844386295
- ReliureLivre broché
- Nombre de pages92
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol: Using Model dependent and Independent Methods and Bioequivalence Study
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3844386297
ISBN 13 : 9783844386295
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Kineticstudy of Diclofenac Sodium from Methocelk15mcr and Cetylalcohol
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(2012)
ISBN 10 : 3844386297
ISBN 13 : 9783844386295
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Kineticstudy of Diclofenac Sodium from Methocelk15mcr and Cetylalcohol
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LAP Lambert Academic Publishing 2012-12
(2012)
ISBN 10 : 3844386297
ISBN 13 : 9783844386295
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol Using Model dependent and Independent Methods and Bioequivalence Study
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LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3844386297
ISBN 13 : 9783844386295
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Description du livre PAP. Etat : New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. N° de réf. du vendeur L0-9783844386295
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol
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Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Current study aimed at the development of a matrix type sustain release Diclofenac tablet, using hydrophilic HPMC and hydrophobic polymer Cetyl alcohol. It was found that hydrophilic Methocel K15 MCR® matrices based tablets showed zero order and hydrophobic cetyl alcohol matrices based tablets were followed first-order kinetics except formulation six (F6 showed zero order profile). The result of dissolution study indicated that formulations containing cetyl alcohol showed better dissolution properties as compared to formulations containing Methocel K15 MCR® in terms of similarity and difference factor. By comparing the dissolution profiles with Voltaren SR® tablet in terms of difference factors and similarity factors, it was revealed that the formulation F-4, F-5 and F-6 exhibited similar drug release profile as that of Voltaren SR® tablet which indicated that these formulations could be bioequivalent with Voltaren SR® tablet in vitro. The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCR® and cetyl alcohol in the form of matrix tablets with similar dissolution profile of patent product Voltaren SR®. 92 pp. Englisch. N° de réf. du vendeur 9783844386295
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol : Using Model dependent and Independent Methods and Bioequivalence Study
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3844386297
ISBN 13 : 9783844386295
Neuf
Taschenbuch
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Description du livre Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Current study aimed at the development of a matrix type sustain release Diclofenac tablet, using hydrophilic HPMC and hydrophobic polymer Cetyl alcohol. It was found that hydrophilic Methocel K15 MCR® matrices based tablets showed zero order and hydrophobic cetyl alcohol matrices based tablets were followed first-order kinetics except formulation six (F6 showed zero order profile). The result of dissolution study indicated that formulations containing cetyl alcohol showed better dissolution properties as compared to formulations containing Methocel K15 MCR® in terms of similarity and difference factor. By comparing the dissolution profiles with Voltaren SR® tablet in terms of difference factors and similarity factors, it was revealed that the formulation F-4, F-5 and F-6 exhibited similar drug release profile as that of Voltaren SR® tablet which indicated that these formulations could be bioequivalent with Voltaren SR® tablet in vitro. The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCR® and cetyl alcohol in the form of matrix tablets with similar dissolution profile of patent product Voltaren SR®. N° de réf. du vendeur 9783844386295
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EUR 49
Autre devise
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol Using Model dependent and Independent Methods and Bioequivalence Study
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3844386297
ISBN 13 : 9783844386295
Neuf
PAP
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Description du livre PAP. Etat : New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. N° de réf. du vendeur L0-9783844386295
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3844386297
ISBN 13 : 9783844386295
Neuf
Couverture souple
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Evaluation vendeur
Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Islam Md. ImamulMd. Imamul Islam, MS in Pharmaceutical Science, Jahangirnagar University, Savar, Dhaka-1342,Researcher in the Protein Biochemistry Laboratory, Chosun University, South Korea.Current study aimed at the development . N° de réf. du vendeur 5476147
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