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An RNA regulates the epigenetic switch at the basis of FSHD: A Polycomb/Trithorax Epigenetic Switch in Muscular Dystrophy - Couverture souple
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Présentation de l'éditeur :
FSHD is an autosomal dominant disease associated with contraction of D4Z4 repeats, mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leading to de-repression of 4q35 genes. Repression by D4Z4 displays similarities with Polycomb-mediated silencing. Polycomb (PcG) and Trithorax (TrxG) group proteins work as counteractors in the epigenetic regulation of gene expression. Transcription of PcG-binding regions can regulate PcG activity. Intriguingly, it is shown here that D4Z4 generates a chromatin-bound RNA selectively in FSHD patients and upon 4q35 de-repression. This transcript is specifically 4q35-associated and is required for 4q35 gene de-repression. Interestingly, the identified RNA promotes the recruitment of the TrxG protein Ash1L to the FSHD locus. Notably, Ash1L is necessary for 4q35 gene de-repression. These results suggest that the RNA functions by recruiting Ash1L to counteract PcG silencing at D4Z4 leading to 4q35 gene de-repression in FSHD. This work provides a nexus for revealing the epigenetic basis of FSHD etiology. Moreover, this study gives insights into the biological function of repetitive elements.
Biographie de l'auteur :
Dr. Daphne S. Cabianca was born in Italy on 19th February 1982. In 2006 she obtained the Degree in Experimental and Applied Biology at the University of Pavia, Italy, full marks with honours. In 2011 she obtained the PhD in Molecular and Cellular Biology, International PhD Program at the Vita-Salute University, Italy and Open University, UK.
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- ÉditeurLAP Lambert Academic Publishing
- Date d'édition2012
- ISBN 10 3846528129
- ISBN 13 9783846528129
- ReliureBroché
- Nombre de pages116
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An RNA regulates the epigenetic switch at the basis of FSHD: A Polycomb/Trithorax Epigenetic Switch in Muscular Dystrophy
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3846528129
ISBN 13 : 9783846528129
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An RNA Regulates the Epigenetic Switch at the Basis of Fshd
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An RNA Regulates the Epigenetic Switch at the Basis of Fshd
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An RNA regulates the epigenetic switch at the basis of FSHD A PolycombTrithorax Epigenetic Switch in Muscular Dystrophy
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LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3846528129
ISBN 13 : 9783846528129
Neuf
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An RNA regulates the epigenetic switch at the basis of FSHD
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Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -FSHD is an autosomal dominant disease associated with contraction of D4Z4 repeats, mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leading to de-repression of 4q35 genes. Repression by D4Z4 displays similarities with Polycomb-mediated silencing. Polycomb (PcG) and Trithorax (TrxG) group proteins work as counteractors in the epigenetic regulation of gene expression. Transcription of PcG-binding regions can regulate PcG activity. Intriguingly, it is shown here that D4Z4 generates a chromatin-bound RNA selectively in FSHD patients and upon 4q35 de-repression. This transcript is specifically 4q35-associated and is required for 4q35 gene de-repression. Interestingly, the identified RNA promotes the recruitment of the TrxG protein Ash1L to the FSHD locus. Notably, Ash1L is necessary for 4q35 gene de-repression. These results suggest that the RNA functions by recruiting Ash1L to counteract PcG silencing at D4Z4 leading to 4q35 gene de-repression in FSHD. This work provides a nexus for revealing the epigenetic basis of FSHD etiology. Moreover, this study gives insights into the biological function of repetitive elements. 116 pp. Englisch. N° de réf. du vendeur 9783846528129
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An RNA regulates the epigenetic switch at the basis of FSHD : A Polycomb/Trithorax Epigenetic Switch in Muscular Dystrophy
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3846528129
ISBN 13 : 9783846528129
Neuf
Taschenbuch
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Description du livre Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - FSHD is an autosomal dominant disease associated with contraction of D4Z4 repeats, mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leading to de-repression of 4q35 genes. Repression by D4Z4 displays similarities with Polycomb-mediated silencing. Polycomb (PcG) and Trithorax (TrxG) group proteins work as counteractors in the epigenetic regulation of gene expression. Transcription of PcG-binding regions can regulate PcG activity. Intriguingly, it is shown here that D4Z4 generates a chromatin-bound RNA selectively in FSHD patients and upon 4q35 de-repression. This transcript is specifically 4q35-associated and is required for 4q35 gene de-repression. Interestingly, the identified RNA promotes the recruitment of the TrxG protein Ash1L to the FSHD locus. Notably, Ash1L is necessary for 4q35 gene de-repression. These results suggest that the RNA functions by recruiting Ash1L to counteract PcG silencing at D4Z4 leading to 4q35 gene de-repression in FSHD. This work provides a nexus for revealing the epigenetic basis of FSHD etiology. Moreover, this study gives insights into the biological function of repetitive elements. N° de réf. du vendeur 9783846528129
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An RNA regulates the epigenetic switch at the basis of FSHD A PolycombTrithorax Epigenetic Switch in Muscular Dystrophy
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3846528129
ISBN 13 : 9783846528129
Neuf
PAP
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Description du livre PAP. Etat : New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. N° de réf. du vendeur L0-9783846528129
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An RNA regulates the epigenetic switch at the basis of FSHD
Edité par
LAP LAMBERT Academic Publishing
(2012)
ISBN 10 : 3846528129
ISBN 13 : 9783846528129
Neuf
Couverture souple
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Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Cabianca Daphne S.Dr. Daphne S. Cabianca was born in Italy on 19th February 1982. In 2006 she obtained the Degree in Experimental and Applied Biology at the University of Pavia, Italy, full marks with honours. In 2011 she obtained th. N° de réf. du vendeur 5496843
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