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Modeling Cellular Signaling Systems: An Abstraction-Refinement Approach - Couverture souple

Hermith, Diana

 
9783846537565: Modeling Cellular Signaling Systems: An Abstraction-Refinement Approach
Couverture souple
ISBN 10 : 384653756X ISBN 13 : 9783846537565
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

At the cellular level, theorize about the molecular mechanisms of cells to communicate with the environment implies to take into consideration concurrent processes, elements, and relationships that define the functionality of cells over time. The cell-membrane, the surface that acts as a boundary contains many receptors which are responsible for interacting with diverse signaling molecules and recognize external information that affects the behavior in a cell. Each receptor detects specific molecules that may bind to it, which activates signaling pathways that regulate molecular mechanisms, the flow and the processing of biochemical information. There is a special class of receptors that constitutes a common target of pharmaceutical drugs, the G protein-coupled receptors (GPCRs). These receptors interact with their respective Guanine nucleotide-binding proteins (G Proteins) to induce an intracellular signaling. In this thesis we study, in a compositional way, interesting biological scenarios in the context of signaling biochemical networks by using the nTCC calculus, a non-deterministic temporal extension of Concurrent Constraint Programming (CCP).

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

At the cellular level, theorize about the molecular mechanisms of cells to communicate with the environment implies to take into consideration concurrent processes, elements, and relationships that define the functionality of cells over time. The cell-membrane, the surface that acts as a boundary contains many receptors which are responsible for interacting with diverse signaling molecules and recognize external information that affects the behavior in a cell. Each receptor detects specific molecules that may bind to it, which activates signaling pathways that regulate molecular mechanisms, the flow and the processing of biochemical information. There is a special class of receptors that constitutes a common target of pharmaceutical drugs, the G protein-coupled receptors (GPCRs). These receptors interact with their respective Guanine nucleotide-binding proteins (G Proteins) to induce an intracellular signaling. In this thesis we study, in a compositional way, interesting biological scenarios in the context of signaling biochemical networks by using the nTCC calculus, a non-deterministic temporal extension of Concurrent Constraint Programming (CCP).

Biographie de l'auteur

Graduated with an honors master degree in Computer Science. With a Bachelor Science degree in Molecular Biology and in Science, Technology and Society. Interested to understand the integration and the interactions of the components in biological systems. A scientist and humanist, who thinks about the complexity and the expression of life.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
384653756X
ISBN 13 
9783846537565
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
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