L'édition de cet ISBN n'est malheureusement plus disponible.
Afficher les exemplaires de cette édition ISBNLes informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
Frais de port :
EUR 3,74
Vers Etats-Unis
Description du livre Etat : New. N° de réf. du vendeur ABLIING23Apr0316110143633
Description du livre PF. Etat : New. N° de réf. du vendeur 6666-IUK-9783848428502
Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Here we present evidence that the transcription factor Teashirt (Tsh) has a role in cell proliferation in Drosophila follicle stem cells (FSC), neuroblasts and S2 cells. In ovaries, Tsh and Hedgehog (Hh) are co-expressed in the terminal filament and cap cells. The characterisation of a new tsh mutation causing female sterility allowed us to show that Tsh acts via Hh-mediated signalling pathway to control FSC proliferation. In this tsh background, the hsGal4 driven expression of tsh or hh partially rescues the abnormal phenotype allowing oogenesis progression. Furthermore, tsh overexpression mimics the hh overexpression associated phenotype. In neuroblasts, mutant tsh alleles are unable to exit mitosis. The phenotypes of double mutants with rod or bub1 resemble the tsh single mutant phenotype, suggesting failure to escape mitosis. Finally, tsh depletion in S2 cells mimics the tsh mutant phenotype in neuroblasts. We propose that during oogenesis, tsh affects FSC proliferation mediating Hh expression. In neuroblasts, tsh may also acts through Hh signalling, since expression of interference hedgehog, was severely downregulated in our DNA microarray analysis. 200 pp. Englisch. N° de réf. du vendeur 9783848428502
Description du livre PAP. Etat : New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. N° de réf. du vendeur L0-9783848428502
Description du livre Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Here we present evidence that the transcription factor Teashirt (Tsh) has a role in cell proliferation in Drosophila follicle stem cells (FSC), neuroblasts and S2 cells. In ovaries, Tsh and Hedgehog (Hh) are co-expressed in the terminal filament and cap cells. The characterisation of a new tsh mutation causing female sterility allowed us to show that Tsh acts via Hh-mediated signalling pathway to control FSC proliferation. In this tsh background, the hsGal4 driven expression of tsh or hh partially rescues the abnormal phenotype allowing oogenesis progression. Furthermore, tsh overexpression mimics the hh overexpression associated phenotype. In neuroblasts, mutant tsh alleles are unable to exit mitosis. The phenotypes of double mutants with rod or bub1 resemble the tsh single mutant phenotype, suggesting failure to escape mitosis. Finally, tsh depletion in S2 cells mimics the tsh mutant phenotype in neuroblasts. We propose that during oogenesis, tsh affects FSC proliferation mediating Hh expression. In neuroblasts, tsh may also acts through Hh signalling, since expression of interference hedgehog, was severely downregulated in our DNA microarray analysis. N° de réf. du vendeur 9783848428502
Description du livre PAP. Etat : New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. N° de réf. du vendeur L0-9783848428502
Description du livre Kartoniert / Broschiert. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Pimentel SilviaDr. Silvia Pimentel has obtained her PhD degree in 2011, here is shown her PhD results. Dr. Rui Gomes (PhD degree in 1994) Professor at Lisbon University (FCUL) works in the fields of Cell Cycle Regulation and Neurosci. N° de réf. du vendeur 5521500