Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Alkaline phosphatase (ALP, ALKP) (EC 126.96.36.199) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation. As the name suggests, alkaline phosphatases are most effective in an alkaline environment. It is sometimes used synonymously as basic phosphatase.