Articles liés à Genome Stability and Human Diseases
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Présentation de l'éditeur :
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting 'bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.
Présentation de l'éditeur :
This comprehensive overview discusses cancer cell biology in relation to Genome stability and Cell cycle regulation. Chapters are devoted to genome stability and anti-cancer drug targets, chromatin factors, DNA repair, apoptosis and other key areas of research.
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- ÉditeurSpringer
- Date d'édition2012
- ISBN 10 9400731256
- ISBN 13 9789400731257
- ReliureBroché
- Nombre de pages356
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Genome Stability and Human Diseases
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Genome Stability and Human Diseases (Subcellular Biochemistry) [Soft Cover ]
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Genome Stability and Human Diseases (Subcellular Biochemistry, 50)
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Description du livre Etat : New. N° de réf. du vendeur ABLIING23Apr0412070049994
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Genome Stability and Human Diseases
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Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Discusses cancer cell biology in relation to Genome stability and Cell cycle regulationUnique assembly of experts in these fields who wrote a comprehensive and deep up-to-date overviewDiscusses models for the understanding of DNA damage-dep. N° de réf. du vendeur 5826186
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Genome Stability and Human Diseases
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Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting 'bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader. 356 pp. Englisch. N° de réf. du vendeur 9789400731257
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Genome Stability and Human Diseases
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Springer Netherlands
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ISBN 13 : 9789400731257
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Description du livre Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting 'bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader. N° de réf. du vendeur 9789400731257
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Genome Stability and Human Diseases
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Description du livre Paperback. Etat : Brand New. 2010 edition. 356 pages. 9.20x6.10x0.81 inches. In Stock. N° de réf. du vendeur x-9400731256
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