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- ÉditeurSpringer
- Date d'édition2011
- ISBN 10 9401083479
- ISBN 13 9789401083478
- ReliureBroché
- Nombre de pages312
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Human Insulin: Clinical Pharmacological Studies in Normal Man by Owens, D.R. [Paperback ]
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(2011)
ISBN 10 : 9401083479
ISBN 13 : 9789401083478
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Description du livre Soft Cover. Etat : new. N° de réf. du vendeur 9789401083478
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Human Insulin: Clinical Pharmacological Studies in Normal Man
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(2011)
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ISBN 13 : 9789401083478
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Description du livre Etat : New. N° de réf. du vendeur ABLIING23Apr0412070057864
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Human Insulin : Clinical Pharmacological Studies in Normal Man
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(2011)
ISBN 10 : 9401083479
ISBN 13 : 9789401083478
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Description du livre Etat : New. N° de réf. du vendeur 20194472-n
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Human Insulin: Clinical Pharmacological Studies in Normal Man
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(2011)
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ISBN 13 : 9789401083478
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Description du livre Etat : New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. N° de réf. du vendeur ria9789401083478_lsuk
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Human Insulin
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Springer Netherlands Okt 2011
(2011)
ISBN 10 : 9401083479
ISBN 13 : 9789401083478
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Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness. 308 pp. Englisch. N° de réf. du vendeur 9789401083478
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Human Insulin: Clinical Pharmacological Studies in Normal Man
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(2011)
ISBN 10 : 9401083479
ISBN 13 : 9789401083478
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Description du livre Paperback. Etat : Brand New. 308 pages. 9.25x6.10x0.70 inches. In Stock. N° de réf. du vendeur x-9401083479
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Human Insulin
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Description du livre Etat : New. Num Pages: 308 pages, biography. BIC Classification: MFGM. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 16. Weight in Grams: 474. . 2011. Softcover reprint of the original 1st ed. 1986. paperback. . . . . N° de réf. du vendeur V9789401083478
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Human Insulin : Clinical Pharmacological Studies in Normal Man
Edité par
Springer Netherlands
(2011)
ISBN 10 : 9401083479
ISBN 13 : 9789401083478
Neuf
Taschenbuch
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Description du livre Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness. N° de réf. du vendeur 9789401083478
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Human Insulin
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(2011)
ISBN 10 : 9401083479
ISBN 13 : 9789401083478
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Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human in. N° de réf. du vendeur 5834884
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Human Insulin
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Springer
(2011)
ISBN 10 : 9401083479
ISBN 13 : 9789401083478
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Description du livre Etat : New. Num Pages: 308 pages, biography. BIC Classification: MFGM. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 16. Weight in Grams: 474. . 2011. Softcover reprint of the original 1st ed. 1986. paperback. . . . . Books ship from the US and Ireland. N° de réf. du vendeur V9789401083478
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