Phosphoinositides II: the Diverse Biological Functions: II (Hardback)
Language: English . Brand New Book. Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization. N° de réf. du libraire AAS9789400730144
A propos du livre :
Titre : Phosphoinositides II: the Diverse Biological...
Éditeur : Springer, Netherlands
Date d'édition : 2012
Reliure : Hardback
Etat du livre : New
Edition : 2012 ed..
Modes de paiement
Modes de paiement acceptés par le vendeur
The Book Depository US
Vendeur AbeBooks depuis 10 septembre 2013
Evaluation du vendeur
All books are shipped in New condition promptly, we are happy to accept returns up to 30 days from purchase. Orders usually ship within 1-2 business days. Domestic Shipments are sent by Royal Mail, and International by Priority Airmail. We are happy to accept returns up to 30 days from purchase. Please contact the seller directly if you wish to return an order. Name of business : The Book Depository Ltd Form of legal entity : A Limited Company Business address: The Book Depository, 60 Holborn Vi...[Pour plus d'information]
Conditions de livraison :
Orders usually ship within 1-2 business days. Domestic Shipments are sent by Royal Mail, and International by Priority Airmail. We are happy to accept returns up to 30 days from purchase. Please contact the seller directly if you wish to return an order.
Description de la librairie : Book Depository is an international bookseller. We ship our books to over 100 countries around the globe and we are always looking to add more countries to the list. We really, really love books and offer millions of titles, currently over 10 million of them, with this figure increasing daily. Living by our motto, 'Bookseller to the World', we focus on offering as many titles as possible to as many customers as possible. Most of our titles are dispatched within 2 business days of your order. Apart from publishers, distributors and wholesalers, we even list and supply books from other retailers! We hope you enjoy our selection and discover your new favorite book.