Image de l'éditeur

T Lymphocyte Subpopulations in Immunotoxicology (Hardback)

0 avis par Goodreads
ISBN 10: 0471971944 / ISBN 13: 9780471971948
Edité par John Wiley and Sons Ltd, United Kingdom, 1998
Neuf(s) Etat : New Couverture rigide
Vendeur The Book Depository US (London, Royaume-Uni)

Vendeur AbeBooks depuis 10 septembre 2013

Quantité : 1

Acheter neuf
Prix conseillé : 400.00
Prix: EUR 225,86 Autre devise
Livraison : EUR 0 De Royaume-Uni vers Etats-Unis Destinations, frais et délais
Ajouter au panier

A propos de cet article

Language: English . Brand New Book. T Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and CD8 suppressor/cytotoxic T cells. It is now apparent that there exists within both populations considerable functional heterogeneity, characterized usually by variable cytokine secretion patterns. Two major subpopulations of T helper (Th) cells have been identified and designated Th1 and Th2, with similar, but less well characterized, sub-types of cytotoxic (Tc) cells having been described also. The discovery of functional subpopulations of Th (and Tc) cells has profoundly influenced our view of the immune response and, in particular, our appreciation of the way in which the immune system can tailor responses to meet challenges of different types. This has also translated into a much more detailed understanding of certain immunopathologic processes and the role of T lymphocytes in the development of allergic, autoimmune and inflammatory diseases. This book explores the role of T lymphocyte subpopulations in the development and expression of immunotoxic effects. Constituent chapters reveal that a consideration of the impact of chemicals on these diverse T cell populations and the polarization of T cell responses has already contributed greatly to our understanding of the mechanisms underlying immunotoxicity, including immune suppression and allergic and autoimmune responses. N° de réf. du libraire AAH9780471971948

Poser une question au libraire

Détails bibliographiques

Titre : T Lymphocyte Subpopulations in ...

Éditeur : John Wiley and Sons Ltd, United Kingdom

Date d'édition : 1998

Reliure : Hardback

Etat du livre :New

Edition : 1. Auflage.

A propos de ce titre

Synopsis :

T Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and CD8 suppressor/cytotoxic T cells. It is now apparent that there exists within both populations considerable functional heterogeneity, characterized usually by variable cytokine secretion patterns. Two major subpopulations of T helper (Th) cells have been identified and designated Th1 and Th2, with similar, but less well characterized, sub-types of cytotoxic (Tc) cells having been described also. The discovery of functional subpopulations of Th (and Tc) cells has profoundly influenced our view of the immune response and, in particular, our appreciation of the way in which the immune system can tailor responses to meet challenges of different types. This has also translated into a much more detailed understanding of certain immunopathologic processes and the role of T lymphocytes in the development of allergic, autoimmune and inflammatory diseases. This book explores the role of T lymphocyte subpopulations in the development and expression of immunotoxic effects. Constituent chapters reveal that a consideration of the impact of chemicals on these diverse T cell populations and the polarization of T cell responses has already contributed greatly to our understanding of the mechanisms underlying immunotoxicity, including immune suppression and allergic and autoimmune responses.

From the Publisher:

A thoroughly comprehensive volume for graduate students and professionals specializing in immunotoxicology, immunopharmacology and clinical allergy. Providing a clear and detailed review of research into functional subpopulations of T lymphocytes, it considers their contribution to immunotoxicology in detail.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Description de la librairie

Book Depository is an international bookseller. We ship our books to over 100 countries around the globe and we are always looking to add more countries to the list. We really, really love books and offer millions of titles, currently over 10 million of them, with this figure increasing daily. Living by our motto, 'Bookseller to the World', we focus on offering as many titles as possible to as many customers as possible. Most of our titles are dispatched within 2 business days of your order. Apart from publishers, distributors and wholesalers, we even list and supply books from other retailers! We hope you enjoy our selection and discover your new favorite book.

Visitez la page d?accueil du vendeur

Conditions de vente :

All books are shipped in New condition promptly, we are happy to accept returns up to 30 days from purchase. Orders usually ship within 1-2 business days. Domestic Shipments are sent by Royal Mail, and International by Priority Airmail. We are happy to accept returns up to 30 days from purchase. Please contact the seller directly if you wish to return an order. Name of business : The Book Depository Ltd Form of legal entity : A Limited Company Business address: The Book Depository, 60 Holborn Vi...

Pour plus d'information
Conditions de livraison :

Orders usually ship within 1-2 business days. Domestic Shipments are sent by Royal Mail, and International by Priority Airmail. We are happy to accept returns up to 30 days from purchase. Please contact the seller directly if you wish to return an order.

Afficher le catalogue du vendeur

Modes de paiement
acceptés par le vendeur

Visa Mastercard American Express Carte Bleue