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Translational Stroke Research (Hardback)

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ISBN 10: 1441995293 / ISBN 13: 9781441995292
Edité par Springer-Verlag New York Inc., United States, 2012
Neuf(s) Etat : New Couverture rigide
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Language: English . Brand New Book. This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design. N° de réf. du libraire SPR9781441995292

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Détails bibliographiques

Titre : Translational Stroke Research (Hardback)

Éditeur : Springer-Verlag New York Inc., United States

Date d'édition : 2012

Reliure : Hardback

Etat du livre :New

Edition : 2012.

A propos de ce titre

Synopsis :

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

From the Back Cover:

Translational Stroke Research: From Target Selection to Clinical Trials is part of “Springer Series in Translational Stroke Research.” Forty-three chapters from leading stroke research groups around the world select future targets and methods for stroke management such as the vasculature and white matter, protein aggregation, neuroglobin, microRNAs, oxidation, soluble epoxide hydrolase, apoptosis, hypoxia-inducible factors, thrombin, toll-like receptor, angiogenesis, membrane potentials and pumps. The book discusses methods to regulate brain temperature and the use of preconditioning in stroke. It also presents new areas of research emphasizing restoration of function with growth factors and stem cells.  It provides multiple animal models of both ischemic and hemorrhagic stroke in order to translate basic preclinical findings to clinical trials with de-risking issues,  therapy delivery methods such as sustained-release and intranasal delivery, and potential therapies including cell therapies, albumin, transcranial laser, microbubbles, and ultrasound. Finally, it debates clinical trial design for analytical methodology, imaging, computation, and innovations.

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