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- ÉditeurSpringer-Verlag New York Inc.
- Date d'édition2008
- ISBN 10 0387097880
- ISBN 13 9780387097886
- ReliureRelié
- Nombre de pages357
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Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization To Human Disease
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ISBN 10 : 0387097880
ISBN 13 : 9780387097886
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Description du livre Etat : Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service. N° de réf. du vendeur ABEOCT23-73506
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Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization To Human Disease
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ISBN 13 : 9780387097886
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Description du livre Etat : New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability. N° de réf. du vendeur ABTR-222974
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Multichain Immune Recognition Receptor Signaling
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Description du livre Etat : New. pp. xxxvii + 169 1st Edition. N° de réf. du vendeur 26480992
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Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization To Human Disease
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Description du livre Etat : New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. This item may ship from the US or our Overseas warehouse depending on your location and stock availability. We Ship to PO BOX Location also. N° de réf. du vendeur ABRR-222974
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Multichain Immune Recognition Receptor Signaling
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Description du livre Etat : New. pp. xxxvii + 169 Illus. N° de réf. du vendeur 7399743
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Multichain Immune Recognition Receptor Signaling
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Springer New York Okt 2008
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Description du livre Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Immunological recognition is a central feature of the adaptive immunity of vertebrates. With the exception of agnathans, which developed an entirely distinct set of immunologically-specific molecules, all vertebrates use a recognition system based on what Achsah Keegan and I suggested in 1992 be termed multichain immune recognition receptors (MIRRs). MIRRs consist of ligand-binding molecules that are immunoglobulin supergene family members associated with signal transducers and enhancers in such a way as both insure precise ligand recognition, discrimination and ampHfication of the signal. Two of the prototypic sets of MIRRs, the T-cell and B-cell receptors, are among the most remarkable recognition molecules known. These are extraordinarily diverse molecules in which the range of ligands that can be potentially recognized prob ably exceeds the actual numbers of lymphocytes in the body. The discovery of the genetic basis of assembling these receptors and understanding how they bind to their cognate antigens are among the most stunning of scientific achievements. Yet these immensely specific binding chains (the heavy/light chain pair for immunoglobulin and the a/p chain pair for most T cells), when expressed as membrane molecules, have no obvious mechanism of signaling. For example, the iH chain cytosolic do main consists of three amino acids (lysine-valine-lysine) and the L chain is not even embedded in the membrane. Furthermore, there is no known direct mechanism to propagate information from the binding domain of the B-cell or T-cell receptors to the membrane-proximal domains of the same chains. 388 pp. Englisch. N° de réf. du vendeur 9780387097886
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Multichain Immune Recognition Receptor Signaling
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Description du livre Gebunden. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. ALEXANDER SIGALOV, PhD, is a Research Assistant Professor in the Department of Pathology at the University of Massachusetts Medical School in Worcester, Massachusetts, USA. His main research interests include protein intrinsic disorder and oligomericity . N° de réf. du vendeur 5909010
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Multichain Immune Recognition Receptor Signaling : From Spatiotemporal Organization to Human Disease
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Description du livre Etat : New. N° de réf. du vendeur 5873389-n
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Multichain Immune Recognition Receptor Signaling : From Spatiotemporal Organization to Human Disease
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(2008)
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ISBN 13 : 9780387097886
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Description du livre Etat : New. N° de réf. du vendeur 5873389-n
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Multichain Immune Recognition Receptor Signaling : From Spatiotemporal Organization to Human Disease
Edité par
Springer New York
(2008)
ISBN 10 : 0387097880
ISBN 13 : 9780387097886
Neuf
Couverture rigide
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Description du livre Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Immunological recognition is a central feature of the adaptive immunity of vertebrates. With the exception of agnathans, which developed an entirely distinct set of immunologically-specific molecules, all vertebrates use a recognition system based on what Achsah Keegan and I suggested in 1992 be termed multichain immune recognition receptors (MIRRs). MIRRs consist of ligand-binding molecules that are immunoglobulin supergene family members associated with signal transducers and enhancers in such a way as both insure precise ligand recognition, discrimination and ampHfication of the signal. Two of the prototypic sets of MIRRs, the T-cell and B-cell receptors, are among the most remarkable recognition molecules known. These are extraordinarily diverse molecules in which the range of ligands that can be potentially recognized prob ably exceeds the actual numbers of lymphocytes in the body. The discovery of the genetic basis of assembling these receptors and understanding how they bind to their cognate antigens are among the most stunning of scientific achievements. Yet these immensely specific binding chains (the heavy/light chain pair for immunoglobulin and the a/p chain pair for most T cells), when expressed as membrane molecules, have no obvious mechanism of signaling. For example, the iH chain cytosolic do main consists of three amino acids (lysine-valine-lysine) and the L chain is not even embedded in the membrane. Furthermore, there is no known direct mechanism to propagate information from the binding domain of the B-cell or T-cell receptors to the membrane-proximal domains of the same chains. N° de réf. du vendeur 9780387097886
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