Handbook of Human Molecular Evolution - Couverture rigide

Couverture rigide

ISBN 10 : 0470517468 ISBN 13 : 9780470517468

Editeur : Wiley–Blackwell, 2008

A propos du livre

Présentation de l'éditeur :

This splendid compendium will be the standardreference work for years to come: a handbook to browse, to consult,to look things up in, and to read with pleasure, wonder andpost–Darwinian exhilaration.
Richard Dawkins

This is a marvellous book It should be in everyuniversity library – preferably in several copies – and everyreader of this journal should add it to their next grantapplication. It really is that good... I have already found thisbook to be invaluable For many years to come, these twovolumes will be the starting point for anyone wishing to find outabout virtually any subject relating to human genetics   Any scientist working on humans or other animals will findmany things in these pages that will stimulate, inform and inspire.The authors, editors and publishers are to be congratulated fortheir work order a copy now! HUMAN GENETICS

The publishers and editors deserve to be congratulatedfor publishing this major book which coincides with the200th anniversary of the birth of Charles Darwin. Thebook is well–timed, with biologists, theologians and sociologistsengaged in intense debate on the Darwinian Theory on the origin ofspecies, evolution and natural selection There is littledoubt that this marvellous publication should be in the library ofuniversities and academic institutions dealing with basic andapplied biology research and education It will not besurprising if the individual academic or researcher decides toinvest in this resource and enrich their personal collection ofleading books in genetics and genomics. GENOMICMEDICINE

A Unique Collection of High–Quality Articles Derivedfrom the Acclaimed Encyclopedia of LifeSciences 

The revolution in human molecular genetics which has taken placeover the last three decades has yielded a wealth of information notonly on the structure and function of our genes, but also on geneexpression, mutation and polymorphic variation. Over the last fiveyears, the focus has moved from genes to genomes. Even though theannotation of our ∼30,000 genes is still in progress, genome–widestudies have already yielded abundant evidence for the signaturesof past selection and adaptive evolution within human genesequences. Further, the completion of the sequencing of the 3billion base–pair human genome, coupled with the increasingavailability of other vertebrate genome sequences, has ushered in anew era of comparative genomics. We are now able toidentify many of the molecular events (from the chromosomal leveldown to the single base–pair) that have occurred during vertebrate,mammalian, primate and hominid evolution. Indeed, the detailedcomparison of the human and chimpanzee genomes has begun to revealsome of the genetic changes that have been involved in thedevelopment of human lineage–specific traits. We are thus acquiringthe ability to ask searching questions about our origins, about thedemographic processes associated with the global radiation ofhumankind, as well as some of the unique adaptations that make ushuman.

Evolutionary biology has become so broad that its impact may befelt across the spectrum of the biological sciences. The aim of theHandbook of Human Molecular Evolution is relativelystraightforward: to bring together under the same cover the manyand varied strands of our knowledge of human/primate/vertebratemolecular evolution. Hence, the 282 chapters that comprisethis essential reference work have been thematically arranged intotwelve sections, covering the whole scope of research intohuman molecular evolution: 

General Concepts in Evolutionary Genetics
Mutation, Adaptation and Natural Selection
Evolutionary and Population Genetics
Human Evolution
Human Genome Evolution
Evolution of Human Gene Structure and Function
Evolution of Gene Expression
Mitochondrial Genome Evolution
Chromosomal Evolution
Comparative Genomics
Evolution and Disease Susceptibility
Analysis of Ancient DNA 

This conceptual outline informed the selection of the chaptersthemselves and the connections between them. Some of these chaptersare intended to be introductory, aimed at undergraduates andnon–specialists. They provide basic information and a list ofrecommended further reading to encourage the reader to explore atopic in more depth. This approach helps the student readerprogress from textbook material to primary literature. Somechapters are overviews that address topics of broad interest andimportance, while others focus on quite specialized topics. Thesechapters are written for postgraduate students and researchworkers; they contain more detailed information and key referencesallowing the reader to investigate a specific area in more depth.This format allows professionals to use the books as a quickreference source.  The chapters are richly supplied withwebsite information to allow access to relevant data sources overthe internet. The self–contained, peer–reviewed articles in thisunique handbook have been written by leading scientists in eachfield. 

Key topics include the evolution of enzyme function, the use ofnucleic acid divergence as a "molecular clock", the origin ofnon–functional or junk DNA, the role of gene duplication in theemergence of novel gene function and the identification ofmolecular changes responsible for various human characteristicsespecially those pertaining to infection, cognition, disease anddisease susceptibility.  

The Handbook of Human Molecular Evolution hasadopted an integrated approach to the study of human evolution andseeks throughout to emphasize the interplay between moleculargenetic concepts and principles on the one hand, and informationacquisition and interpretation on the other. In this way, it ishoped that the documents of evolutionary history written into the fabric of our genome, will become accessible tothe widest possible audience.

Revue de presse :

"This is a marvellous book .For many years to come, thesetwo volumes will be the starting point for anyone wishing to findout about virtually any subject relating to human genetics."( Human Genetics, December 2008)

The publishers and editors deserve to be congratulatedfor publishing this major book which coincides with the200th anniversary of the birth of Charles Darwin."(Genomic Medicine) 

This splendid compendium will be the standardreference work for years to come: a handbook to browse, to consult,to look things up in, and to read with pleasure, wonder andpost–Darwinian exhilaration. ( Richard Dawkins)

"This is a marvellous book For many years to come, thesetwo volumes will be the starting point for anyone wishing to findout about virtually any subject relating to human genetics."(Human Genetics)

The publishers and editors deserve to be congratulatedfor publishing this major book which coincides with the200th anniversary of the birth of Charles Darwin."(Genomic Medicine) 

À propos de cette édition

• Éditeur: Wiley–Blackwell
• Date d'édition: 2008
• ISBN 10: 0470517468
• ISBN 13: 9780470517468
• Reliure: Relié
• Numéro d'édition: 2
• Nombre de pages: 1744