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Edité par Humana Pr Inc, Totowa, NJ, 2004
ISBN 10 : 1588292207ISBN 13 : 9781588292209
Livre
Cloth. Etat : Very Good Plus. 168 pp. Tightly bound. Corners not bumped. NOTE: The word "USED" neatly stamped on top fore-edge. Text is Free of Markings.
Edité par Humana Pr Inc, Totowa, NJ, 2003
ISBN 10 : 158829045XISBN 13 : 9781588290458
Livre
Cloth. Etat : Very Good Plus. 428 pp. Tightly bound. Corners not bumped. NOTE: The word "USED" neatly stamped on top fore-edge. Rounding to cloth at head of spine. Text is Free of Markings.
Edité par Humana Pr Inc, Totowa, NJ, 2005
ISBN 10 : 1588295486ISBN 13 : 9781588295484
Livre
Cloth. Etat : Very Good Plus. 515 pp. Tightly bound. Corners not bumped. Text is Free of Markings. NOTE: The word "USED" neatly stamped on top fore-edge.
Edité par Humana Press Inc., United States, Totowa, NJ, 1998
ISBN 10 : 0896034305ISBN 13 : 9780896034303
Vendeur : WorldofBooks, Goring-By-Sea, WS, Royaume-Uni
Livre
Paperback. Etat : Very Good. Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders. This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins. The book has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged.
Edité par Humana Press Inc., United States, Totowa, NJ, 2004
ISBN 10 : 1588295001ISBN 13 : 9781588295002
Vendeur : WorldofBooks, Goring-By-Sea, WS, Royaume-Uni
Livre
Paperback. Etat : Fine. Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforcedfor example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.
Edité par Humana Pr Inc, Totowa, NJ, 2003
ISBN 10 : 1588290557ISBN 13 : 9781588290557
Vendeur : Louisville Book Net, Louisville, KY, Etats-Unis
Livre
Hardcover. Etat : Good-. 2003, hard cover, slight edgewear, light soiling on outer page edges, 698 p. Book.
Edité par Humana Press Inc., Totowa, NJ, U.S.A., 1995
ISBN 10 : 0896032906ISBN 13 : 9780896032903
Vendeur : PsychoBabel & Skoob Books, Didcot, Oxfordshire, OXON, Royaume-Uni
Livre Edition originale
Hardcover. Etat : Very Good. Etat de la jaquette : No Dust Jacket. First Edition. Govt.Ref.Lib.Copy. Hardly Used. Library sticker on spine and FEP; library stamp on FEP; text tight and bright. Used.
Edité par Humana Press Inc., Totowa, NJ, 2006
ISBN 10 : 1588293793ISBN 13 : 9781588293794
Vendeur : Foggy Mountain Books, Oakdale, TN, Etats-Unis
Livre
Hardcover. Etat : As New. No Jacket. Glossy illustrated boards. 1st printing, 2006. No jacket as published. Like New. Firmly bound, unread. Crisp, bright and unmarked. No remainder mark. Like New condition.
Edité par Humana Press Inc.,U.S., Totowa, NJ, 1993
ISBN 10 : 0896032515ISBN 13 : 9780896032514
Vendeur : Antiquariat Tröger, Lörrach, Allemagne
Livre Edition originale
Original Cloth. Etat : Very Fine. Etat de la jaquette : Very Fine. First Edition. xi, 219 pages, very fine condition.
Edité par Humana Press Inc., Totowa, NJ, 2015
ISBN 10 : 1493922521ISBN 13 : 9781493922529
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs. Chapters focus on exploring recent studies that reveal how certain long non protein-coding RNAs accumulate in specific nuclear bodies and regulate the function of the bodies by serving as architectural components or controlling the dynamics of associating protein components. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Nuclear Bodies and Noncoding RNAs: Methods and Protocols serves as a guideline for further study into the sophisticated regulation of gene expression. This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Pr Inc, Totowa, NJ, 1988
ISBN 10 : 0896031179ISBN 13 : 9780896031173
Vendeur : a2zbooks, Burgin, KY, Etats-Unis
Livre
Hardcover. Etat : Very Good. Etat de la jaquette : Very Good. text has minor markings in it. Quantity Available: 1. ISBN: 0896031179. ISBN/EAN: 9780896031173. Pictures of this item not already displayed here available upon request. Inventory No: 1560747707.
Edité par Totowa, NJ: Humana Press Inc.,U.S., 2004
ISBN 10 : 1588291030ISBN 13 : 9781588291035
Vendeur : D2D Books, Berkshire, Royaume-Uni
Livre
Hardcover. Etat : New. No Jacket. Humana Press Inc.,U.S. hardback, 2004, A BRAND NEW BOOK IN PRISTINE ORDER, UNUSED. Full refund if not satisfied. 24 hour despatch.
Edité par Humana Press Inc., Totowa, NJ, 2019
ISBN 10 : 149399073XISBN 13 : 9781493990733
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital relationships between genotype and phenotype. After a few educational primers, the book continues with sections on sequence homology and alignment, phylogenetic methods to study genome evolution, methodologies for evaluating selective pressures on genomic sequences as well as genomic evolution in light of protein domain architecture and transposable elements, population genomics and other omics, and discussions of current bottlenecks in handling and analyzing genomic data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that lead to the best results. Authoritative and comprehensive, Evolutionary Genomics: Statistical and Computational Methods, Second Edition aims to serve both novices in biology with strong statistics and computational skills, and molecular biologists with a good grasp of standard mathematical concepts, in moving this important field of study forward. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
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Edité par Humana Press Inc., Totowa, NJ, 2016
ISBN 10 : 1493946129ISBN 13 : 9781493946129
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Paperback. Etat : new. Paperback. In this volume expert researchers in the field detail the many methods for further research into regulation of mitochondrial function. Chapters focus on mitochondria with other cellular components, discussing how these interactions influence the dynamics of mitochondrial structure and biogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Mitochondrial Regulation: Methods and Protocols seeks to aid advanced undergraduates, graduates, postgraduates, and beginning researchers in the areas of molecular and cellular biology, biochemistry and bioenergetics. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 1988
ISBN 10 : 0896031543ISBN 13 : 9780896031548
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Paperback. Etat : new. Paperback. This volume reflects clinical and experimental research on selenium. Papers focus on biomedical and ecological aspects of this element, with special emphasis on the distribution of selenium in body organs and fluids, its role and mechanisms in human disease, its effects on cancer, its usefulness in treatment of disease, manifestations of selenium deficiency in various countries, and aspects of selenium supplementation. This volume reflects clinical and experimental research on selenium. Papers focus on biomedical and ecological aspects of this element, with special emphasis on the distribution of selenium in body organs and fluids, and its role and mechanisms in human disease. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2018
ISBN 10 : 1493976583ISBN 13 : 9781493976584
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre Edition originale
Hardcover. Etat : new. Hardcover. This volume details cutting-edge protocols on the characterization of the genome, epigenome, proteome, metabolome and single-cell transcriptome of tumors and tumor-derived cultures. Chapters focus on subpopulations of cells with stem-like properties, laser capture microdissection, and modeling human glioma with human embryonic stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glioblastoma: Methods and Protocols aims to support researchers seeking new and refined protocols to better decrypt this tumor. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2009
ISBN 10 : 1934115495ISBN 13 : 9781934115497
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. As increasing global population and continuing economic development ensure the need for further production and cultivation of maize, the necessity of the application of transgenic technology to this model species and crop plant grows steadily. In Transgenic Maize: Methods and Protocols, experts in the various disciplines of the field contribute readily reproducible protocols covering such topics as transformation methods, transgenic maize in research, the analysis of transgenic plants, and breeding with transgenes. Written in the highly successful Methods in Molecular Biology series format, the chapters present brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Cutting-edge and easy to use, Transgenic Maize: Methods and Protocols will greatly aid researchers wishing to use these procedures in their own laboratories, and will provide readers with a better understanding of the experiments being performed by cooperators or fee-for-service labs. In this book, experts in the various disciplines of the field contribute readily reproducible protocols covering such topics as transformation methods, transgenic maize in research, the analysis of transgenic plants, and breeding with transgenes. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2018
ISBN 10 : 1493988042ISBN 13 : 9781493988044
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre Edition originale
Hardcover. Etat : new. Hardcover. This detailed volume compiles the best methodologies and experimental techniques to profile and extract maximal data from brain tumor stem cells (BTSCs), the experimental paradigm for brain cancer research that offers insights into cancer stem cell populations that may drive not only tumor initiation but tumor recurrence and patient relapse. The BTSC model recapitulates scientific observations made in brain cancer patients, and these chapters provide the reader with a comprehensive understanding of the skills and techniques that will unlock data from this most informative subset of cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Brain Tumor Stem Cells: Methods and Protocols serves as an ideal guide for researchers seeking to better understand the complexities of brain cancer. This detailed volume compiles the best methodologies and experimental techniques to profile and extract maximal data from brain tumor stem cells (BTSCs), the experimental paradigm for brain cancer research that offers insights into cancer stem cell populations that may drive not only tumor initiation but tumor recurrence and patient relapse. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2012
ISBN 10 : 1607611945ISBN 13 : 9781607611943
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. A basic understanding of cardiovascular physiology is essential for optimal patient care. This practical book provides a concise tutorial of all the essential aspects of cardiovascular hemodynamics and the techniques used to assess cardiovascular performance. A high-yield reference, this book is replete with figures, tracings, tables, and clinical pearls that reinforce the basic tenets of hemodynamics. From identifying key findings of the patient history and physical exam to correlating hemodynamic tracings with acute clinical presentations, this book arms the reader with the tools necessary to handle any hemodynamic-related situation. A basic understanding of cardiovascular physiology is essential for optimal patient care. From identifying key findings of the patient history and physical exam to correlating hemodynamic tracings with acute clinical presentations, this book arms the reader with the tools necessary to handle any hemodynamic-related situation. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2015
ISBN 10 : 1493931660ISBN 13 : 9781493931668
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. The second edition of this volume focuses on applied bioinformatics with specific applications to crops and model plants. Plant Bioinformatics: Methods and Protocols is aimed at plant biologists who have an interest in, or requirement for, accessing and manipulating huge amounts of data being generated by high throughput technologies. This book would also be of interest to bioinformaticians and computer scientists who would benefit from an introduction to the different tools and systems available for plant research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and software, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, Plant Bioinformatics: Methods and Protocols helps researchers with the increasing volume and diversity of data from different plants and also the integration of multiple diverse forms of data. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2011
ISBN 10 : 1607614669ISBN 13 : 9781607614661
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Paperback. Etat : new. Paperback. Breast Cancer is the most common tumor in women and the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist. Breast cancer is the most common tumor in women. It is the second leading cause of cancer deaths worldwide. In this book, international authorities offer a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2009
ISBN 10 : 1607612461ISBN 13 : 9781607612469
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease. As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2018
ISBN 10 : 1493976001ISBN 13 : 9781493976003
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. This volume focuses on the analysis of miRNA and its many components such as targets and expression profiling, regulation of gene expression, miRNA detection in biofluids, and its application in cancer and wound healing. The chapters in this book explore topics thats cover biogenesis, isolation and profiling of miRNA, exosomal miRNAs, and the study of the functional significance of miRNAs. The chapters also cover screening miRNAs in mR-302/367 induced iPSCs, exosomal miRNAs from iPSC-derived cardiomyocytes proliferation, and the recently discovered sugar-like RNA glycylglycerins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, MicroRNA Protocols, Third Edition is a valuable resource that provides researchers with a comprehensive study of miRNAs and its numerous components and uses. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
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Edité par Humana Press Inc., Totowa, NJ, 2018
ISBN 10 : 1493977733ISBN 13 : 9781493977734
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre Edition originale
Hardcover. Etat : new. Hardcover. This detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epigenome Editing: Methods and Protocols will be of great assistance to people new to the field but also to those already engaged, as epigenetic editing is still a relatively unexplored field with many issues to be resolved. This detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
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Offres neuf à partir de EUR 145,60
Trouvez également Edition originale
Edité par Humana Press Inc., Totowa, NJ, 2018
ISBN 10 : 1493977792ISBN 13 : 9781493977796
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre Edition originale
Hardcover. Etat : new. Hardcover. This detailed book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the in vitro investigation of chromothripsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chromothripsis: Methods and Protocols serves as a vital resource for cell biologists, molecular biologists, cytogeneticists, and geneticists investigating chromothripsis, but also for students and researchers new to the field of chromothripsis and genomic instability. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the in vitro investigation of chromothripsis. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2015
ISBN 10 : 1493926357ISBN 13 : 9781493926350
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. This book provides an overview of pulmonary hypertensive diseases, the current understanding of their pathobiology, and a contemporary approach to diagnosis and treatment. It discusses the definition and classification of these disorders and the epidemiology of pulmonary arterial hypertension (PAH); explores the approach to diagnosis and evaluation via methods such as echocardiography, right heart catheterization, and cardiopulmonary exercise testing; describes the major drug classes used to treat PAH and the cell signaling pathways that they target as well as adjunct and investigative therapies; and highlights special situations that are particularly challenging in the management of PAH. Written by experts in their respective fields, Diagnosis and Management of Pulmonary Hypertension is a valuable resource for pulmonologists, cardiologists, and practitioners in internal medicine and critical care. This book provides an overview of pulmonary hypertensive diseases, the current understanding of their pathobiology, and a contemporary approach to diagnosis and treatment. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2009
ISBN 10 : 1934115711ISBN 13 : 9781934115718
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. Given the popularity and utility of Saccharomyces cerevisiae, yeast-based functional genomics and proteomics technologies, developed over the past decade, have contributed greatly to our understanding of bacterial, yeast, fly, worm and human gene functions. In Yeast Functional Genomics and Proteomics: Methods and Protocols, experts in the field contribute stand-alone protocols suitable for daily use in research laboratories. The volume examines methods from the most major and fundamental techniques to more cutting-edge, advanced concepts. As part of the highly successful Methods in Molecular Biology series, the chapters are clearly formatted with introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easy to use, Yeast Functional Genomics and Proteomics: Methods and Protocols is an ideal reference for both yeast researchers and those who wish to use yeast as a model system for the further study of functional genomics and proteomics. Yeast-based functional genomics and proteomic technologies have increased our understanding of bacterial, yeast, fly, worm and human gene functions. In this book, experts in the field offer stand-alone protocols suitable for daily use in research laboratories. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2010
ISBN 10 : 1617377023ISBN 13 : 9781617377020
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre Edition originale
Paperback. Etat : new. Paperback. This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. The new therapies have led to significant improvements in patient function, quality of life and survival. In this book, expert authors describe these new therapies. It will be of interest not only to cardiologists, pulmonary specialists and rheumatologists, but also many nurses and pharmacotherapists. This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2010
ISBN 10 : 1617376752ISBN 13 : 9781617376757
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre Edition originale
Paperback. Etat : new. Paperback. This is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas. This is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Edité par Humana Press Inc., Totowa, NJ, 2009
ISBN 10 : 1934115665ISBN 13 : 9781934115664
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Livre
Hardcover. Etat : new. Hardcover. Each generation in a sexually reproducing organism such as a fly or a mouse passes through the bottleneck of meiosis, which is the specialized cell division that gives rise to haploid reproductive cells (sperm, eggs, spores, etc. ). The principal function of meiosis is to reduce the genome complement by half, which is accomplished through sequential execution of one round of DNA replication followed by two rounds of chromosome segregation. Within the extended prophase between DNA replication and the first meiotic division in most organisms, homologous maternal and paternal chromosomes pair with one another and undergo homologous recombination, which establishes physical connections that link the homologous chromosomes until the time they are separated at anaphase I. Recombination also serves to increase genetic diversity from one generation to the next by breaking up linkage groups. The unique chromosome dynamics of meiosis have fascinated scientists for well over a century, but in recent years there has been an explosion of new information about how meiotic chromosomes pair, recombine, and are segregated. Progress has been driven by advances in three main areas: (1) genetic identification of meiosis-defective mutants and cloning of the genes involved; (2) development of direct physical assays for DNA intermediates and products of recombination; and (3) increasingly sophisticated cy- logical methods that describe chromosome behaviors and the spatial and temporal patterns by which specific proteins associate with meiotic chromosomes. Within the extended prophase between DNA replication and the first meiotic division in most organisms, homologous maternal and paternal chromosomes pair with one another and undergo homologous recombination, which establishes physical connections that link the homologous chromosomes until the time they are separated at anaphase I. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.