springer new york okt 2015 (43 résultats)

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Based on courses given at Eötvös Loránd University (Hungary) over the past 30 years, this introductory textbook develops the central concepts of the analysis of functions of one variable - systematically, with many examples and illustrations, and in a manner that builds upon, and sharpens, the student's mathematical intuition. The book provides a solid grounding in the basics of logic and proofs, sets, and real numbers, in preparation for a study of the main topics: limits, continuity, rational functions and transcendental functions, differentiation, and integration. Numerous applications to other areas of mathematics, and to physics, are given, thereby demonstrating the practical scope and power of the theoretical concepts treated.In the spirit of learning-by-doing, Real Analysis includes more than 500 engaging exercises for the student keen on mastering the basics of analysis. The wealth of material, and modular organization, of the book make it adaptable as a textbook for courses of various levels; the hints and solutions provided for the more challenging exercises make it ideal for independent study. 500 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This text presents the Eulerian numbers in the context of modern enumerative, algebraic, and geometric combinatorics. The book first studies Eulerian numbers from a purely combinatorial point of view, then embarks on a tour of how these numbers arise in the study of hyperplane arrangements, polytopes, and simplicial complexes. Some topics include a thorough discussion of gamma-nonnegativity and real-rootedness for Eulerian polynomials, as well as the weak order and the shard intersection order of the symmetric group.The book also includes a parallel story of Catalan combinatorics, wherein the Eulerian numbers are replaced with Narayana numbers. Again there is a progression from combinatorics to geometry, including discussion of the associahedron and the lattice of noncrossing partitions.The final chapters discuss how both the Eulerian and Narayana numbers have analogues in any finite Coxeter group, with many of the same enumerative and geometric properties.There are four supplemental chapters throughout, which survey more advanced topics, including some open problems in combinatorial topology. This textbook will serve a resource for experts in the field as well as for graduate students and others hoping to learn aboutthese topicsfor the first time. 476 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This text for the first or second year undergraduate in mathematics, logic, computer science, or social sciences, introduces the reader to logic, proofs, sets, and number theory. It also serves as an excellent independent study reference and resource for instructors. Adapted from Foundations of Logic and Mathematics: Applications to Science and Cryptography 2002 Birkh user, this second edition provides a modern introduction to the foundations of logic, mathematics, and computers science, developing the theory that demonstrates construction of all mathematics and theoretical computer science from logic and set theory. The focuses is on foundations, with specific statements of all the associated axioms and rules of logic and set theory, and provides complete details and derivations of formal proofs. Copious references to literature that document historical development is also provided.Answers are found to many questions that usually remain unanswered: Why is the truth table for logical implication so unintuitive Why are there no recipes to design proofs Where do these numerous mathematical rules come from What issues in logic, mathematics, and computer science still remain unresolved And the perennial question: In what ways are we going to use this material Additionally, the selection of topics presented reflects many major accomplishments from the twentieth century and includes applications in game theory and Nash's equilibrium, Gale and Shapley's match making algorithms, Arrow's Impossibility Theorem in voting, to name a few. From the reviews of the first edition:'.All the results are proved in full detail from first principles.remarkably, the arithmetic laws on the rational numbers are proved, step after step, starting from the very definitions!.This is a valuable reference text and a useful companion for anybody wondering how basic mathematical concepts can be rigorously developed within set theory.'-MATHEMATICAL REVIEWS 'Rigorous and modern in its theoretical aspect, attractive as a detective novel in its applied aspects, this paper book deserves the attention of both beginners and advanced students in mathematics, logic and computer sciences as well as in social sciences.'-Zentralblatt MATH 404 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This SpringerBrief equips readers to develop defensible fire safety designs for a range of concrete structures. It identifies current gaps in the research and provides a more complete understanding of the structural and thermal response of contemporary Post-tensioned (PT) concrete structures to fire. The brief includes chapters on contemporary construction using PT concrete, previous structural fire test research programs, recent research programs, real fire case studies, and current research needs. It explores the progression of PT concrete structures, looking at the sustainability and aesthetic benefits, the ongoing development of stronger concretes, and best practice guidance for improving safety in the event of fire.Designed for practitioners and researchers in fire engineering, this brief is a valuable tool for those studying the impact of fire on concrete, fire safety designs, and building safety optimization. Advanced-level students in civil engineering will also find the content useful. 104 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The collected essays in this volume present an overview and state-of-the-field of traditional and recently developed methodological approaches to the study of bilingual reading comprehension. It critically reviews and examines major findings from classical behavioral approaches such as the visual moving window, rapid-serial visual presentation (RSVP), and eye-tracking, as well as newly developing neuropsycholinguistic methodologies such as Event-Related Potentials (ERPS), and Functional Magnetic Resonance Imaging (fMRI). Written to address a timely topic, Methods in Bilingual Reading Comprehension Research updates the field of bilingual reading by critically examining the contributions of the various behavioral and technologically-based reading techniques used to understand psychological processes underlying written language comprehension. Each topic is covered first from a theoretical, and then from an experimental, viewpoint. Moreover, the volume contributes to the development and establishment of Bilingual Reading as a subfield of bilingual sentence processing and fills a significant gap in the literature on bilingual language processing and thought.Significantly, Methods in Bilingual Reading Comprehension Research presents an overall view of some of the typical psycholinguistic techniques and approaches, as well as proposing other possible tasks that may prove viable in investigating such theoretical issues as bilingual lexical ambiguity resolution, or how bilingual speakers might resolve multiple sources of potentially conflicting information as they comprehend sentences and discourse during the communicative process. In addition, to aid reader comprehension and encourage readers to acquire 'hands on' experience in the creation and development of experiments in the realm of bilingual reading research, each chapter includes a list of key words, suggested student research projects, and questions to both help the reader review the chapter and expand upon the reading. With its comprehensive coverage of a crucial subfield of psycholinguistics and language processing, Methods in Bilingual Reading Comprehension Research is an invaluable and informative resource for all students and researchers in bilingualism, neurolinguistics, bilingual cognition, and other related fields. 404 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Dynamic secrets are constantly generated and updated from messages exchanged between two communication users. When dynamic secrets are used as a complement to existing secure communication systems, a stolen key or password can be quickly and automatically reverted to its secret status without disrupting communication.'Dynamic Secrets in Communication Security' presents unique security properties and application studies for this technology. Password theft and key theft no longer pose serious security threats when parties frequently use dynamic secrets. This book also illustrates that a dynamic secret based security scheme guarantees impersonation attacks are detected even if an adversary steals a user's password or their key is lost.Practitioners and researchers working in network security or wireless communications will find this book a must-have reference. 'Dynamic Secrets in Communication Security' is also a valuable secondary text for advanced-level students in computer science and electrical engineering. 148 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Money. The root of all evil Arguably. Essential to our lives Certainly. A main driver of human thought, emotion, and action Absolutely--and psychology and its related fields are getting closer to understanding its complex role in human behavior and in society. The Psychological Science of Money brings together classic and current findings on the myriad ways money affects brain, mind, and behavior to satisfy not only our needs for material gain, but also for autonomy and self-worth. Leading experts trace the links between early concepts of value and modern symbolic meanings of wealth, in addition to identifying the areas of the human brain that together act as its financial center. This cross-disciplinary analysis helps clarify the neuroscience behind pathological gambling, the critical role of time in financial decisions, and the impact of money on diverse personal activities and interpersonal relationships. Included in the coverage: Materiality, symbol, and complexity in the anthropology of money.The (relative and absolute) subjective value of money.Conscious and unconscious influences of money: two sides of the same coin A life-course approach to dealing with monetary gains and lossesMotivation and cognitive control: beyond monetary incentives.An integrative perspective on the science of getting paid.The psychological science of spending.The unique role of money in society makes The Psychological Science of Money a singularly fascinating resource with a wide audience among social psychologists, industrial and organizational psychologists, economists, sociologists, anthropologists, and public policymakers. 276 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book guides undergraduate students in the use of Maxima-a computer algebra system-in solving problems in classical mechanics. It functions well as a supplement to a typical classical mechanics textbook.When it comes to problems that are too difficult to solve by hand, computer algebra systems that can perform symbolic mathematical manipulations are a valuable tool. Maxima is particularly attractive in that it is open-source, multiple-platform software that students can download and install free of charge. Lessons learned and capabilities developed using Maxima are easily transferred to other, proprietary software. 272 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This monograph provides both an introduction to and a thorough exposition of the theory of rate-independent systems, which the authors have been working on with a lot of collaborators over 15 years. The focus is mostly on fully rate-independent systems, first on an abstract level either with or even without a linear structure, discussing various concepts of solutions with full mathematical rigor. Then, usefulness of the abstract concepts is demonstrated on the level of various applications primarily in continuum mechanics of solids, including suitable approximation strategies with guaranteed numerical stability and convergence. Particular applications concern inelastic processes such as plasticity, damage, phase transformations, or adhesive-type contacts both at small strains and at finite strains. A few other physical systems, e.g. magnetic or ferroelectric materials, and couplings to rate-dependent thermodynamic models are considered as well. Selected applications are accompanied by numerical simulations illustrating both the models and the efficiency of computational algorithms.In this book, the mathematical framework for a rigorous mathematical treatment of 'rate-independent systems' is presented in a comprehensive form for the first time. Researchers and graduate students in applied mathematics, engineering, and computational physics will find this timely and well written book useful. 684 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -From the Introduction: ' Marston Morse was born in 1892, so that he was 33 years old when in 1925 his paper Relations between the critical points of a real-valued function of n independent variables appeared in the Transactions of the American Mathematical Society. Thus Morse grew to maturity just at the time when the subject of Analysis Situs was being shaped by such masters as Poincaré, Veblen, L. E. J. Brouwer, G. D. Birkhoff, Lefschetz and Alexander, and it was Morse's genius and destiny to discover one of the most beautiful and far-reaching relations between this fledgling and Analysis; a relation which is now known as Morse Theory. In retrospect all great ideas take on a certain simplicity and inevitability, partly because they shape the whole subsequent development of the subject. And so to us, today, Morse Theory seems natural and inevitable. This whole flight of ideas was of course acclaimed by the mathematical World.it eventually earned him practically every honor of the mathematical community, over twenty honorary degrees, the National Science Medal, the Legion of Honor of France, .' 932 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents state-of-the-art methods for reliable detection of epigenetic changes in the nervous system. Epigenetic Methods in Neuroscience Research guides readers through methods for the analyses of chromatin remodeling, transposable elements, non-coding RNAs, such as miRNAs, and circadian oscillations, including: analysis of DNA methylation in neuronal and glial cells or small tissue samples; sensitive method for quantification of alternative methylated forms of cytosines by liquid chromatography/mass spectrometry; affinity-based detection of modified cytosines by immunohistochemistry or methylated DNA immunoprecipitation; chromatin immunoprecipitation, or ChIP; miRNA high-throughput profiling and the in situ detection of miRNA subtle expression in the brain; analysis of genes with alternative 3'UTRs; and the cite-specific delivery of chromatin-modifying drugs. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Concise and easy-to-use, Epigenetic Methods in Neuroscience Research provides multidisciplinary epigenetic approach to study genome, and neural, plasticity that will help the reader to successfully address the challenges associated with neurodevelopmental, psychiatric, and neurodegenerative disorders. 272 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The third edition of this volume focuses on experimental models that are useful for investigating various aspects of cytoskeleton structure and function. Animal, plant, protist, and fungal models highlight twenty-four chapters that provide detailed protocols for live and fixed-cell imaging, dynamics of cytoskeleton components, cell and organelle motility, and genetics and proteomics. Written in the highly successful Methods in Molecular Biology series format, protocols in each chapter are up-to-date menus organized in a useful step-by-step format appropriate for novice and established investigators. Each chapter is equipped with a valuable notes section that provides a troubleshooting guide and helpful, and often unpublished, technical information aimed at ensuring success with implementation of the protocols.Authoritative and thorough, Cytoskeleton Methods and Protocols, Third Edition helps researchers expand their understanding of cytoskeleton structure and function. 448 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents a comprehensive collection of methods that have been instrumental to the current understanding of bacterial persisters. Chapters in the book cover topics ranging from general methods for measuring persister levels in Escherichia coli cultures, protocols for the determination of the persister subpopulation in Candida albicans, quantitative measurements of Type I and Type II persisters using ScanLag, to in vitro and in vivo models for the study of the intracellular activity of antibiotics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Bacterial Persistence: Methods and Protocols brings together the most respected researchers in bacterial persistence whose studies will remain vital to understanding this field for many years to come. 256 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume aims to describe clearly and in detail the key practical skills involved in cartilage tissue engineering. Methods are outlined for isolation and expansion of chondrocytes and stem cells; differentiation; synthesis and application of three-dimensional scaffolds; design and operation of bioreactors; in vivo testing of engineered constructs; and molecular and functional analysis of cartilage cells and tissues. Frequently used technologies are covered, as well as more recent advances in inspirational areas such as 'smart' biomaterial development, novel bioreactor design, -omics analysis, and genetic manipulation of matrix synthesis. The key procedures discussed either underpin the progress already achieved in cartilage tissue engineering or are indicative of the direction of future research in the area. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible step-by-step laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Cartilage Tissue Engineering: Methods and Protocols is a useful resource that informs the scientific community about the experimental work covering a broad range of objectives for cartilage synthesis and regeneration. 304 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This extensive volume covers basic and advanced aspects of peptide antibody production, characterization and uses. Although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For example, peptide antibodies which are dependent on specific posttranslational modifications are of great interest, such as phosphorylation, citrullination and others, while different forms of recombinant peptide antibodies are gaining interest, notably nanobodies, single chain antibodies, TCR-like antibodies, among others. Within this volume, those areas are covered, as well as several technical and scientific advances: solid phase peptide synthesis, peptide carrier conjugation and immunization, genomics, transcriptomics, proteomics and elucidation of the molecular basis of antigen presentation and recognition by dendritic cells, macrophages, B cells and T cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Comprehensive and authoritative, Peptide Antibodies: Methods and Protocols serves as an ideal reference for researchers exploring this vital and expansive area of study. 380 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed volume explores the most popular antigen production and delivery strategies that have been tested in veterinary species. Viral vectors as well as genetic and protein subunit vaccines or large scale protein production systems are considered as well as an updated view of most options available for vaccine development, including the data obtained through experimental trials which contributes to the exploration and understanding of the immune mechanisms and immune correlates relevant in protection among different animal species. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Vaccine Technologies for Veterinary Viral Diseases: Methods and Protocols facilitates access to well-established protocols to those beginning in this interesting and laborious field as well as providing important basic knowledge when attempting a novel vaccine design or platform. 280 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume reviews available mouse models of atherosclerosis, basic aspects of disease initiation and progression, and the visualization of atherosclerotic lesions with invasive and non-invasive techniques that are widely used both in basic research and in the clinic. The chapters catalogue a wide range of in vitro and in vivo experimental methods used for atherosclerosis research, including thorough protocols and valuable notes based on the authors' personal wet lab experience. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Methods in Mouse Atherosclerosis will be a valuable working guide for researchers performing mouse-based atherosclerosis studies. 416 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed volume focuses on methods for the characterization of aggregation processes that lead to the formation of amyloid fibrils and amyloid oligomers which feature in the etiology of a variety of human disorders collectively known as amyloidoses. The scope of the collection includes techniques for visualizing early steps on the amyloid formation pathway, methods for capturing and characterizing oligomeric, potentially toxic, intermediates, strategies for preparing and characterizing mature amyloid fibrils and approaches for understanding templating and transmission of amyloid aggregates. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Protein Amyloid Aggregation: Methods and Protocols serves as an ideal guide for biochemists and biophysicists with an interest in elucidating the mechanisms of protein amyloid formation, as well as chemists, pharmacologists and clinicians with an interest in leveraging an understanding of such mechanisms for the purpose of therapeutic development. 328 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed book contains chapters using unbiased approaches such as chemical and transposon mutagenesis, as well as a protocol for allelic exchange, to make targeted mutants in Staphylococcus, as generating mutants of this bacteria can be accomplished in many ways, depending on the intended changes. Using these methods, the authors have been successful at making mutants that span individual single-nucleotide changes in the chromosome to whole genome mutant libraries. The latter strategy provides a useful tool for high-throughput screening, while single nucleotide changes are an elegant way of teasing apart the importance of single nucleotides in gene expression or to create specific amino acid substitutions to examine protein function. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and authoritative, The Genetic Manipulation of Staphylococci: Methods and Protocols serves as a vital resource and guide to scientists in the Staphylococcus community as they pursue their studies on these bacteria. 196 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume focuses on malaria vaccinology, and introduces researchers to a complete overview of the protocols and tools used by molecular and cellular malariologists. The chapters within this book talk about interventions concerning all aspects of life cycle progression--measuring antibody responses to blood stage parasite survival, the T Cell responses engendered by attenuated sporozoite vaccinations, and the unique effect on transmission of antibodies that target the mosquito stage of the life cycle. Additionally, methods concerning the ability to generate targeted gene deletions and replacements in the genome of Plasmodium parasites convey how Plasmodium parasite phenotypes can be created to precise specifications. More recently, the potential power of humanized mouse models of disease progression have been demonstrated and are also discussed in the book. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Malaria Vaccines: Methods and Protocols is a useful and unique resource for any aspiring malaria vaccinologists because of the volume's exquisitely detailed methodologies that are not typically found in published literature. 320 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides detailed molecular analysis of the associated pathways and cell types involved in Celiac Disease, and embraces new technologies such as next generation sequencing. The book is divided into three parts: Part I gives a background overview with a number of reviews to describe the history and nature of the disease, its diagnosis, the role of animal models, and study designs for investigating genetic susceptibility. Part II describes molecular techniques, including tissue culture, isolation and cloning of relevant cell types, high content analysis of biopsies, and HLA genotyping. The final part of the book begins with an outline of scripting for data management, focusing on tools that are freely available to researchers who wish to explore them. It also describes analysis pipelines for bioinformatics prediction of antigenicity, quality control and analysis of GWAS data, and transcriptome analysis by next generation sequencing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, Celiac Disease: Methods and Protocols brings together novel and more traditional methods in molecular biology and immunology, in order to provide a tool-kit for all stages for Celiac Disease research-from the practicalities of identifying, obtaining, stabilizing and maintaining high quality samples, to molecular analysis and bioinformatics. 248 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is comprised of a collection of experimental protocols for common techniques and strategies used to study the biogenesis of b-barrel outer membrane proteins in Gram-negative bacteria. The BAM Complex: Methods and Protocols guides readers through methods on the function of the BAM complex, the roles played by each of the individual components, the expression and purification of the components, crystallization and structure determination of the components, and how the individual Bam components may assemble into a functional complex. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, The BAM Complex: Methods and Protocols will serve as an invaluable reference for those interested in studying the BAM complex. 300 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides a collection of cutting-edge strategies in siRNA delivery that were developed and refined over the years with tried-and-true methods. Written by a team of internationally renowned authors, this book describes, in detail, a variety of successful siRNA delivery methods, including peptide-based nanoparticles, liposomes, exosomes, polymers, aptamers, and viral vehicles. Written in the highly successful Methods in Molecular Biology series format, each proven protocol includes brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and authoritative, SiRNA Delivery Methods: Methods and Protocols, will provide researchers, educators, clinicians, and biotechnology specialists with a broad understanding of the issues in siRNA delivery and how they can be overcome strategically. 328 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This expert volume provides insights into the technological fundamentals together with a comprehensive overview of the potentialities of peptide microarray technology in basic research and clinical assays. Advancements made in recent years in peptide library synthesis, immobilization chemistry and array production have created a foundation from which different new applications are derived, extending the ways in which peptide microarray technology is applied every day. Divided into three sections, the book covers cutting-edge methods and technology, chemoselective strategies for peptide immobilization, and peptide microarrays for medical applications. Written for the high successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls.Fully updated and authoritative, Peptide Microarrays: Methods and Protocols, Second Edition seeks to encourage scientists to apply current peptide array protocols to the study of interesting new biochemical and medical questions and to assist researchers aiming at developing new methods to further develop peptide microarray technology. 312 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware - This volume provides a comprehensive collection of protocols on new technology across various model organisms. Chapters describe species-specific methods to generate new mutants the content is completed by chapters on natural TAL effectors, TAL element DNA binding principles, TALEN target site prediction, and methods for the efficient construction of TALEN coding regions. While addition chapter focus on the application of TALEN as sequence-specific nucleases and TAL based gene activators or inhibitors and the visualization of chromatin dynamics in live cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, TALENs: Methods and Protocols aims to ensure successful results in the further study of this vital field. 288 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume focuses on screening and profiling kinase inhibitors or activators. Chapters in this book cover several facets of the drug discovery processes starting with target identification, and assay development and screening chemical libraries for hit identification and lead optimization. The profiling portion of Kinase Screening and Profiling: Methods and Protocols discusses several strategies and techniques that are required to minimize off target hits and reduce cellular toxicities that are caused by liability kinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Timely and authoritative, Kinase Screening and Profiling: Methods and Protocols, will benefit scientists and researchers who are interested in exploring the role of kinases in academic, as well as pharmaceutical research. 236 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The theory of numbers continues to occupy a central place in modern mathematics because of both its long history over many centuries as well as its many diverse applications to other fields such as discrete mathematics, cryptography, and coding theory. The proof by Andrew Wiles (with Richard Taylor) of Fermat's last theorem published in 1995 illustrates the high level of difficulty of problems encountered in number-theoretic research as well as the usefulness of the new ideas arising from its proof.The thirteenth conference of the Canadian Number Theory Association was held at Carleton University, Ottawa, Ontario, Canada from June 16 to 20, 2014. Ninety-nine talks were presented at the conference on the theme of advances in the theory of numbers. Topics of the talks reflected the diversity of current trends and activities in modern number theory. These topics included modular forms, hypergeometric functions, elliptic curves, distribution of prime numbers, diophantine equations, L -functions, Diophantine approximation, and many more. This volume contains some of the papers presented at the conference. All papers were refereed. The high quality of the articles and their contribution to current research directions make this volume a must for any mathematics library and is particularly relevant to researchers and graduate students with an interest in number theory. The editors hope that this volume will serve as both a resource and an inspiration to future generations of researchers in the theory of numbers. 256 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This thorough volume aims to provide pharmaceutical engineers with an introduction to the current state of the art in modeling and simulation of pharmaceutical processes and to summarize a number of practical applications of relevant methodologies in drug product development. Chapters include explorations of simulation and modeling methodologies, data collection and analysis, development of novel sensing techniques, development and integration of individual unit models, optimization approaches for data-based models, design space evaluation techniques, informatics-based methodologies, and emerging topics in pharmaceutical process development. As a part of the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and implementation advice that will make the transition into the laboratory as smooth as possible.Authoritative and cutting edge, Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture seeks to promote research into process systems methodologies and their application in pharmaceutical product and process development, which will undoubtedly become an increasingly important area in the future. 404 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume aims to provide the most recent advances in techniques for studying gene expression regulation at the post-transcriptional level. Post-Transcriptional Gene Regulation, Second Edition is organized in six sections describing bioinformatics approaches for studying post-transcriptional regulation, various expression profiling approaches, protein-RNA interaction and non-coding RNA investigation techniques, methods for profiling RNA modifications, and other techniques such as alternative translation initiation or polyadenylation sites determination. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Post-Transcriptional Gene Regulation, Second Edition is a versatile resource to researchers studying post-transcriptional regulation, introducing the most recent techniques and providing a comprehensive guide to their implementation. 368 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Readers will find grouped together here the most recent observations, current theoretical models and present understanding of the coupled atmosphere, magnetosphere and solar wind system. The book begins with a general discussion of mass, energy and momentum transport in magnetodiscs. The physics of partially ionized plasmas of the giant planet magnetodiscs is of general interest throughout the field of space physics, heliophysics and astrophysical plasmas; therefore, understanding the basic physical processes associated with magnetodiscs has universal applications. The second chapter characterizes the solar wind interaction and auroral responses to solar wind driven dynamics. The third chapter describes the role of magnetic reconnection and the effects on plasma transport. Finally, the last chapter characterizes the spectral and spatial properties of auroral emissions, distinguishing between solar wind drivers and internal driving mechanisms. The in-depth reviews provide an excellent reference for future research in this discipline. 340 pp. Englisch.