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Edité par Springer Paris Dez 2014, 2014
ISBN 10 : 2817807677ISBN 13 : 9782817807676
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book gathers the educational lectures and the texts of the main presenta tions given at the 4th International Congress on Anticancer Chemotherapy which took place in February 1993 in Paris and was attended by 5 000 oncologists from all continents, physicians, students and nurses. This book aspires to give update of the most scientific and clinical aspects of modern oncology. It aims also at showing the prospects that are opened by the rapid progress of cancer biology. The editors are grateful to the authors whose scholarship de fines the quality of the book. Educational lectures The pathogenesis of human cancer metastasis I] Fidler Cancer is a collection of malignancies with each cancer of each organ consist ing of numerous subsets. This biologic and clinical heterogeneity is probably due to the different etiologies, origins, and selection pressures. Despite this heterogeneity, all malignant neoplasms have a uniform characteristic : the ability to invade host tissues and produce metastases. Clinical observations of cancer patients and studies with experimental rodent tumors have revealed that cer tain tumors produce metastasis to specific organs independent of vascular anat omy, rate of blood flow, and number of tumor cells delivered to each organ. The distribution and fate of hematogeneously disseminated, radiolabelled tumor cells in experimental rodent systems amply demonstrate that tumor cells reach the microvasculature of many organs. 932 pp. Englisch.
Edité par Springer Paris Dez 2014, 2014
ISBN 10 : 2817805151ISBN 13 : 9782817805153
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 228 pp. Englisch.
Edité par Springer Paris Dez 2014, 2014
ISBN 10 : 2817805143ISBN 13 : 9782817805146
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Biologics have revolutionised the treatment of many severe conditions, delivering exceptional clinical results but also producing exceptionally high prices. As patents expire, copies and price competition are expected throughout the world. However, due to the intrinsic heterogeneity and molecular complexity of biologic medicinal products, their copies cannot simply be authorized under the 'generic rule' valid for small chemical entities. In response, a dedicated regulation was issued in the European Union. It is based on the concept of 'biological medicinal products similar to a biological reference product', or 'biosimilars'. This book analyses the context of biotechnological production and addresses the European legal framework for biosimilar market approval. It highlights post-market authorisation issues, such as Risk Management Plans and substitution of products, and outlines some other issues, such as cost management and international nomenclature. This book is primarily intended for hospital-based physicians and pharmacists. It will also be a valuable resource for all actors from all countries who want to better understand the emergence of these new medicinal products within the European context. 108 pp. Englisch.
Edité par Springer Paris Dez 2014, 2014
ISBN 10 : 2817805127ISBN 13 : 9782817805122
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry. 460 pp. Englisch.
Edité par Springer Paris Dez 2014, 2014
ISBN 10 : 2817805178ISBN 13 : 9782817805177
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is the first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course. This vessel has been considered for long as out of surgical reach leaving many different pathologies not or incompletely treated. The surgical exposure and control of the vertebral artery not only permit to treat lesions of the vertebral artery wall or developed in contact to it but also to improve the access to the intervertebral foramen (tumors, osteophytes), to the anterior aspect of the spinal cord (tumors, spondylotic spurs), to the foramen magnum and to the jugular foramen.This book written by leading experts includes all aspects of vertebral artery surgery from anatomy to imaging, surgical techniques and pathologies; it is illustrated by many figures especially operative views and schematic drawings so that the beginner as well as the experienced surgeon find useful information.One of the editors of this book (B. GEORGE) was recently awarded the Olivecrona award for his work on the surgery of the vertebral artery. 700 pp. Englisch.