Vendeur : California Books, Miami, FL, Etats-Unis
EUR 36,32
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
Vendeur : Lucky's Textbooks, Dallas, TX, Etats-Unis
EUR 53,92
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
Vendeur : California Books, Miami, FL, Etats-Unis
EUR 62
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
EUR 53,69
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New. In.
Edité par VDM Verlag Dr. M�ller 2008-04-08, 2008
ISBN 10 : 3836490013 ISBN 13 : 9783836490016
Langue: anglais
Vendeur : Chiron Media, Wallingford, Royaume-Uni
EUR 52,99
Quantité disponible : 10 disponible(s)
Ajouter au panierPaperback. Etat : New.
Edité par GRIN Verlag, GRIN Verlag Jul 2020, 2020
ISBN 10 : 3346206017 ISBN 13 : 9783346206015
Langue: anglais
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
EUR 17,95
Quantité disponible : 2 disponible(s)
Ajouter au panierTaschenbuch. Etat : Neu. Neuware -Academic Paper from the year 2020 in the subject Biology - Genetics / Gene Technology, grade: 9.0, , course: Cell Biology and Genetics, language: English, abstract: Nucleic acids have proven to be viable targets for small molecule drugs. While many examples of such drugs are detailed in the literature, only a select few have found practical use in a clinical setting. These currently employed nucleic acid targeting therapies suffer from either debilitating off-target side effects or succumb to a resistance mechanism of the target. The need for new small molecules that target nucleic acids is evident.However, designing a novel drug to bind to DNA or RNA requires a detailed understanding of exactly what binding environments each nucleic acid presents. In an effort to broaden this knowledge, the work presented in this thesis details the binding location and affinity of known and novel nucleic acid binding small molecules with targets ranging from simple RNA secondary structure all the way to the complex structure of ribosomal RNA. Specifically, it is shown that the anthracycline classes of antineoplastics prefer to bind at or near mismatch base pairs in both physiologically relevant iron responsive element RNA hairpin constructs as well as DNA hairpin constructs presenting mismatched base pairs.Also characterized in this thesis is a novel class of topoisomerase II / histone deacetylase inhibitor conjugates that display a unique affinity for DNA over RNA. Finally, the novel class of macrolide-peptide conjugates, known as peptolides, is shown to retain potent translation inhibition of the prokaryotic ribosome and identification of a novel binding site for the anthracycline class of drugs and the characterization of the two novel drug designs presented in this thesis will undoubtedly aid in the effort to design and discover new molecules that aim for nucleic acid targets.Books on Demand GmbH, Überseering 33, 22297 Hamburg 32 pp. Englisch.
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
EUR 17,95
Quantité disponible : 1 disponible(s)
Ajouter au panierTaschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Academic Paper from the year 2020 in the subject Biology - Genetics / Gene Technology, grade: 9.0, , course: Cell Biology and Genetics, language: English, abstract: Nucleic acids have proven to be viable targets for small molecule drugs. While many examples of such drugs are detailed in the literature, only a select few have found practical use in a clinical setting. These currently employed nucleic acid targeting therapies suffer from either debilitating off-target side effects or succumb to a resistance mechanism of the target. The need for new small molecules that target nucleic acids is evident.However, designing a novel drug to bind to DNA or RNA requires a detailed understanding of exactly what binding environments each nucleic acid presents. In an effort to broaden this knowledge, the work presented in this thesis details the binding location and affinity of known and novel nucleic acid binding small molecules with targets ranging from simple RNA secondary structure all the way to the complex structure of ribosomal RNA. Specifically, it is shown that the anthracycline classes of antineoplastics prefer to bind at or near mismatch base pairs in both physiologically relevant iron responsive element RNA hairpin constructs as well as DNA hairpin constructs presenting mismatched base pairs.Also characterized in this thesis is a novel class of topoisomerase II / histone deacetylase inhibitor conjugates that display a unique affinity for DNA over RNA. Finally, the novel class of macrolide-peptide conjugates, known as peptolides, is shown to retain potent translation inhibition of the prokaryotic ribosome and identification of a novel binding site for the anthracycline class of drugs and the characterization of the two novel drug designs presented in this thesis will undoubtedly aid in the effort to design and discover new molecules that aim for nucleic acid targets.
Vendeur : preigu, Osnabrück, Allemagne
EUR 17,95
Quantité disponible : 5 disponible(s)
Ajouter au panierTaschenbuch. Etat : Neu. Effect of Small Molecules on Nucleic Acid Stability and Improvements to RNA Structure Prediction | Kehinde Sowunmi | Taschenbuch | 32 S. | Englisch | 2020 | GRIN Verlag | EAN 9783346206015 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.
Edité par Walter de Gruyter, Berlin, 2013
ISBN 10 : 3110284596 ISBN 13 : 9783110284591
Langue: anglais
Vendeur : Research Ink, Takoma Park, MD, Etats-Unis
EUR 88,58
Quantité disponible : 1 disponible(s)
Ajouter au panierHardback. Etat : As new. xxii + 408 pp. book.
EUR 114,50
Quantité disponible : 1 disponible(s)
Ajouter au panierEtat : new.
Vendeur : preigu, Osnabrück, Allemagne
EUR 51,65
Quantité disponible : 5 disponible(s)
Ajouter au panierTaschenbuch. Etat : Neu. SARNA-Predict: An Algorithm for RNA Folding | Based on Free Energy MinimizationTechniques, a Permutation-based Simulated Annealing Algorithm for Ribonucleic Acid Secondary Structure Prediction | Tsang, Herbert H. | Taschenbuch | Kartoniert / Broschiert | Englisch | 2013 | VDM Verlag Dr. Müller | EAN 9783836490016 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu.
Vendeur : Mispah books, Redhill, SURRE, Royaume-Uni
EUR 118,27
Quantité disponible : 1 disponible(s)
Ajouter au panierPaperback. Etat : Like New. Like New. book.
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
EUR 133,84
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New. In.
Vendeur : Lucky's Textbooks, Dallas, TX, Etats-Unis
EUR 158,13
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
EUR 159,72
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
EUR 158,53
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
Vendeur : liu xing, Nanjing, JS, Chine
EUR 149,26
Quantité disponible : 1 disponible(s)
Ajouter au panierpaperback. Etat : New. Language:Chinese.Paperback. Pub Date: 2024-02 Pages: 244 Publisher: Science Press This book introduces the structural characteristics of RNA. especially the characteristics of RNA tertiary structure. conformational sampling representation model. Rosetta framework. cell deconvolution algorithm. transcription factor binding site prediction algorithm. specific site prediction algorithm. etc.; studies the RNA tertiary structure prediction algorithm and complexity. the construction of conformation.
EUR 157,26
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New. In.
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
EUR 157,26
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New. In.
EUR 157,25
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
EUR 178,93
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
EUR 178,03
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : As New. Unread book in perfect condition.
EUR 190,43
Quantité disponible : 4 disponible(s)
Ajouter au panierEtat : New. pp. 412.
Vendeur : California Books, Miami, FL, Etats-Unis
EUR 194,87
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New.
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
EUR 180,68
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New. In.
Vendeur : Books Puddle, New York, NY, Etats-Unis
EUR 192,01
Quantité disponible : 4 disponible(s)
Ajouter au panierEtat : New. 1st ed. 2023 edition NO-PA16APR2015-KAP.
EUR 178,20
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : As New. Unread book in perfect condition.
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
EUR 183,03
Quantité disponible : Plus de 20 disponibles
Ajouter au panierEtat : New. In.
Edité par Springer-Verlag New York Inc., New York, NY, 2023
ISBN 10 : 1071627678 ISBN 13 : 9781071627679
Langue: anglais
Vendeur : Grand Eagle Retail, Bensenville, IL, Etats-Unis
EUR 200,42
Quantité disponible : 1 disponible(s)
Ajouter au panierHardcover. Etat : new. Hardcover. This book explores recent progress in RNA secondary, tertiary structure prediction, and its application from an expansive point of view. Because of advancements in experimental protocols and devices, the integration of new types of data as well as new analysis techniques is necessary, and this volume discusses additional topics that are closely related to RNA structure prediction, such as the detection of structure-disrupting mutations, high-throughput structure analysis, and 3D structure design. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to quality research results. Authoritative and practical, RNA Structure Prediction serves as a valuable guide for both experimental and computational RNA researchers. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Vendeur : preigu, Osnabrück, Allemagne
EUR 129,50
Quantité disponible : 5 disponible(s)
Ajouter au panierTaschenbuch. Etat : Neu. RNA Structure Prediction | Risa Karakida Kawaguchi (u. a.) | Taschenbuch | xxii | Englisch | 2024 | Springer | EAN 9781071627709 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.