100 Years of Human Chorionic Gonadotropin: Reviews and New Perspectives. Cet article n’est pas disponible.100 Years of Human Chorionic Gonadotropin: Reviews and New Perspectives

100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics.

100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification.

100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.

Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of "Trophoblast Disease Update". He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research.

Dr. Butler attained his PhD from the University of London and after a Post-Doctoral Fellowship at Yale University School of Medicine he became an Assistant Professor at the University of New Mexico with the USA hCG Reference Service. Steve returned to the UK and, following positions at Queen Mary University of London and London Metropolitan University he spent seven years at Middlesex University as Reader (Associate Professor) in Biomedical Diagnostics. Dr Butler has been a Director for medical diagnostics companies and and is now a consultant biomedical diagnostics expert with a particular interest in diagnostics and therapeutics relating to hCG in pregnancy and cancer. He has published over 80 peer reviewed scientific articles, reviews, letters, patents, abstracts and book chapters in the field of molecular diagnostics. He is a global opinion leader on the structure and function of human chorionic gonadotropin (hCG) and its role as a diagnostic marker in fertility, pregnancy and cancer.