Synopsis
Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases.How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.
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À propos de l'auteur
Angus C. Nairn is currently Associate Professor at The Rockefeller University. He has published a large number of papers concerned with the structure and regulation of protein kinases and phosphatases involved in signal transduction, particularly with respect to signalling by calcium.
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Ion Channel Regulation. (= Advances in Second Messenger and Phosphoprotein Research, Vol. 33).
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San Diego etc.: Academic Press, 1999
ISBN 10 : 0120361337
ISBN 13 : 9780120361335
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Hardcover/Pappeinband. Etat : Gut. 318 pages. Good. Ex-library with usual library markings. Clean pages without underlinings or remarks. Sprache: Englisch Gewicht in Gramm: 710. N° de réf. du vendeur 791248
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Ion Channel Regulation.
Edité par
Academic Press. San Diego & London., 1999
ISBN 10 : 0120361337
ISBN 13 : 9780120361335
Ancien ou d'occasion
Couverture rigide
Vendeur : avelibro OHG, Dinkelscherben, Allemagne
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Etat : Gut. XX, 318 P. Inside with the usual library stamps and inscriptions, partially crossed out, otherwise in very clean condition. English Language. Advances in Second Messenger and Phosphoprotein Research. Volume 33. Part I: Protein Phosphorylation./ Part II: Closely Associated Proteins./ Part III: Second Messengers.; - With Illustr. deu B12-01-02C|235|15017BB Sprache: Deutsch Gewicht in Gramm: 444 23,5 x 15,5 cm. Original Hardboard. Good condition. N° de réf. du vendeur 16572
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Advances in Second Messenger and Phosphoprotein Research, Volume 33 : Ion Channel Regulation
Edité par
Academic Press, USA, 1998
ISBN 10 : 0120361337
ISBN 13 : 9780120361335
Ancien ou d'occasion
Couverture rigide
Vendeur : The Book Exchange, Macclesfield, CHESH, Royaume-Uni
Évaluation du vendeur 5 sur 5 étoiles
Hardcover. Etat : Very Good. 0120361337. Pictorial Board Hardcover, from closed pharmaceutical company library, light scuff on back cover. Appears unread, colour fade on spine. 334 pages, index, illustrated with charts, tables and diagrams. Volume 33: Reviews ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases. How do cells regulate the activity of these channels? How might we restore their normal function? In "Ion Channel Regulation", many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity. Among its key features, it reviews brain function at the fundamental, molecular level; describes key systems that control signaling between and within cells; and explains how channels are used to stimulate growth and changes to activity of the nucleus and genome. Contents clean, tight and bright. Book. N° de réf. du vendeur 20581
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Advances in Second Messenger and Phosphoprotein Research, Volume 33 : Ion Channel Regulation
Edité par
Academic Press, USA, 1998
ISBN 10 : 0120361337
ISBN 13 : 9780120361335
Ancien ou d'occasion
Couverture rigide
Vendeur : The Book Exchange, Macclesfield, CHESH, Royaume-Uni
Évaluation du vendeur 5 sur 5 étoiles
Hardcover. Etat : Near Fine. 0120361337. Pictorial Board Hardcover, from closed pharmaceutical company library, felt tip mark on page edges. Appears unread, colour fade on spine. 334 pages, index, illustrated with charts, tables and diagrams. Volume 33: Reviews ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases. How do cells regulate the activity of these channels? How might we restore their normal function? In "Ion Channel Regulation", many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity. Among its key features, it reviews brain function at the fundamental, molecular level; describes key systems that control signaling between and within cells; and explains how channels are used to stimulate growth and changes to activity of the nucleus and genome. Contents clean, tight and bright. Book. N° de réf. du vendeur 022685
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Ion Channel Regulation, Volume 33 (Advances in Second Messenger and Phosphoprotein Research)
Edité par
Academic Press, 1999
ISBN 10 : 0120361337
ISBN 13 : 9780120361335
Ancien ou d'occasion
Couverture rigide
Vendeur : Mispah books, Redhill, SURRE, Royaume-Uni
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Hardcover. Etat : Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book. N° de réf. du vendeur ERICA75401203613375
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