Eukaryotic Transcription Factors - Couverture rigide

Couverture rigide

ISBN 10 : 0124371701 ISBN 13 : 9780124371705

Editeur : Academic Press Inc, 1991

Synopsis

Intended for final year undergraduate and postgraduate students in molecular biology and biochemistry, this book discusses in detail information currently available on transcription factors, emphasizing common motifs, themes and mechanisms. It summarizes the major families, describes the mechanics of activation and repression of eukaryotic genes by transcription factors, and explains the relationship between the structure and function of these factors. Furthermore, it highlights the importance of transcription factors during the development, differentiation and transformation of eukaryotic cells, and provides the principles behind the methods employed to study transcription factors in vivo and in vitro.

A propos du livre

Présentation de l'éditeur

Familiarity with the mechanisms of eukaryotic gene regulation is now essential for scientists and students in both clinical and basic disciplines. However, the vast array of transcription factors, which are central to such regulation, can prove daunting to students and newcomers to this fascinating field of molecular genetics. The Third Edition of Eukaryotic Transcription Factors provides the reader with a clear and concise understanding not only of transcription factors, but also of their vital role in the regulation of transcription in different cell types during development and in disease.
Revised and completely up-to-date, the Third Edition of Eukaryotic Transcription Factors has been extensively rewritten to reflect the rapid advances in the field. These include the emerging roles of specific co-activator molecules such as CBP in the action of a number of different transcription factors emphasizing particularly their ability to modulate chromatin structure. New sections cover current methods for determining DNA binding specificity, regulation by protein degradation and processing, Pax family transcription factors, and novel anti-oncogenic transcription factors, as well as a discussion of transcription factors in human diseases. A special new color section illustrates the various aspects of transcription factor structure.

Emphasising common motifs, themes and mechanisms this volume covers:
* Major families of eukaryotic transcription factors
* Mechanisms of gene activation and repression
* Structure-function relationships
* Their roles in inducible and cell type-specific gene expression, development, differentiation, and human diseases including cancer
* Methods of study in vivo and in vitro

Revue de presse

Reviews of Previous Editions
"A standard for the genre... presented with great clarity...profusely illustrated... admirably up-to-date."
--THE LANCET

Détails de l'édition

• Éditeur: Academic Press Inc
• Date d'édition: 1991
• Langue: anglais
• ISBN 10: 0124371701
• ISBN 13: 9780124371705
• Reliure: Relié
• Nombre de pages: 288
• Éditeur: Latchman David S.
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible