Synopsis
Disruption of mitochondrial energy production occurs commonly during cell injury and death. Efforts to understand mechanisms involved in toxic cell injury and to develop protective treatments therefore require a definition of the role of mitochondrial dysfunction. This volume approaches mitochondrial preparation and functional assessment from the perspective of toxic cell injury, with chapters contributed by experts representing a great diversity of biomedical disciplines. It is conveniently divided into six sections, addressing general methods, "in vivo" assessment, structure, detoxication and metabolic targets, bioenergetic and transport functions, and genetic analysis. The variety of approaches and subjects reflects the fundamental importance of mitochondria in aerobic cell survival. This volume should be of interest to researchers and students in toxicology, veterinary toxicology, toxicologic pathology, pharmacology and clinical biochemistry. It should provide a useful contemporary collection of papers critical to the research of all who are investigating mechanisms of cell injury.
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