Receptors for Extracellular Matrix - Couverture rigide

Couverture rigide

ISBN 10 : 0124833659 ISBN 13 : 9780124833654

Editeur : Academic Press Inc, 1991

Synopsis

Aimed at researchers and graduate students in cell and developmental biology, biochemistry, neurobiology, immunology, and pathology, with interests in basic research or medical implications of extracellular matrix. This volume provides an in-depth review of new primary literature on structure and function of matrix receptors, an area of cell biology research. Many aspects of cell and developmental biology (as well as neurobiology, immunology and pathology), are concerned with matrix receptors, which provide an interface for signals involved in cell movement, attachment, development and assembly. The book integrates information about several families of matrix receptors and highlights receptors for extracellular matrix components, cell-matrix interactions in development, effects of extracellular matrix on gene expression and integrins.

A propos du livre

Présentation de l'éditeur

Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers.

Détails de l'édition

• Éditeur: Academic Press Inc
• Date d'édition: 1991
• Langue: anglais
• ISBN 10: 0124833659
• ISBN 13: 9780124833654
• Reliure: Relié
• Nombre de pages: 330
• Éditeur: McDonald John A., Mecham Robert P.
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible