L'édition de cet ISBN n'est malheureusement plus disponible.
Afficher les exemplaires de cette édition ISBNOf the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property.
Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
Frais de port :
EUR 11,13
De Italie vers Etats-Unis
Description du livre Etat : new. Questo è un articolo print on demand. N° de réf. du vendeur 161ad9dee2535d48848b97f6af8ebc7e
Description du livre Hardcover. Etat : new. New. Fast Shipping and good customer service. N° de réf. du vendeur Holz_New_0128010762
Description du livre Etat : New. N° de réf. du vendeur 24829762-n
Description du livre Hardcover. Etat : New. N° de réf. du vendeur 6666-ELS-9780128010761
Description du livre Hardcover. Etat : new. New Copy. Customer Service Guaranteed. N° de réf. du vendeur think0128010762
Description du livre Etat : new. N° de réf. du vendeur FrontCover0128010762
Description du livre Hardcover. Etat : new. Brand New Copy. N° de réf. du vendeur BBB_new0128010762
Description du livre Etat : New. N° de réf. du vendeur 24829762-n
Description du livre Hardcover. Etat : new. Prompt service guaranteed. N° de réf. du vendeur Clean0128010762
Description du livre Etat : New. Book is in NEW condition. N° de réf. du vendeur 0128010762-2-1