Articles liés à Autophagy: Cancer, Other Pathologies, Inflammation,...

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Couverture rigide

 
9780128029374: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Couverture rigide
ISBN 10 : 0128029374 ISBN 13 : 9780128029374
Editeur : Academic Press Inc, 2016

Synopsis

Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington's disease, Parkin's disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.

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À propos de l'auteur

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Academic Press Inc
Date d'édition
2016
Langue
anglais
ISBN 10 
0128029374
ISBN 13 
9780128029374
Reliure
Relié
Numéro d'édition
1
Nombre de pages
418
Éditeur
Hayat M. A.
Coordonnées du fabricant
non disponible
Personne responsable
Yeepin GmbH
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