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Synopsis
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
À propos de l'auteur
Studies from Pizzo’s laboratory identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies. Cell surface GRP78 functions as a signaling receptor promoting tumor proliferation and suppressing apoptosis. Patients with a number of malignancies mount an autoimmune response to GRP78 and these antibodies, which bind to the NH2 terminal domains of GRP78, are receptor agonists whose appearance is a marker of poor prognosis. More recently, his lab has shown that antibodies directed against the COOH-terminal domain of GRP78 are receptor antagonists which may have therapeutic potential for treating patients whose tumors express GRP78 on the cell surface.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
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Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Edité par
Academic Press, 2018
ISBN 10 : 0128123516
ISBN 13 : 9780128123515
Ancien ou d'occasion
Soft cover
Edition originale
Vendeur : killarneybooks, Inagh, CLARE, Irlande
Évaluation du vendeur 5 sur 5 étoiles
Soft cover. Etat : Very Good. 1st Edition. Paperback, xii + 132 pages, NOT ex-library. Short creases to corners and edges. Pages are clean and bright with unmarked text, free of inscriptions and stamps, firmly bound. Gently shelfworn covers; spine free of vertical creases. -- This volume provides a comprehensive review of the emerging and paradigm-shifting role of cell surface-expressed GRP78 (78-kDa glucose-regulated protein) in signal transduction. It challenges the traditional view of GRP78 as solely an endoplasmic reticulum-resident chaperone protein. The collected essays from leading researchers in the field detail the mechanisms by which GRP78 translocates to the cell surface and functions as a receptor. The work explores the critical role of this cell surface GRP78 in regulating key cellular processes, including cell proliferation, apoptosis, and angiogenesis, with a particular focus on its implications for cancer biology and the development of targeted therapies. N° de réf. du vendeur 011228
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EUR 19,90
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Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Edité par
Elsevier Science Publishing Co Inc, 2018
ISBN 10 : 0128123516
ISBN 13 : 9780128123515
Ancien ou d'occasion
Paperback
Vendeur : World of Books (was SecondSale), Montgomery, IL, Etats-Unis
Évaluation du vendeur 5 sur 5 étoiles
Paperback. Etat : Very Good. Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. N° de réf. du vendeur 00095629928
Acheter D'occasion
EUR 123,78
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Expédition nationale : Etats-Unis
Quantité disponible : 1 disponible(s)
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Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Edité par
Elsevier Science & Technology, Academic Press, 2018
ISBN 10 : 0128123516
ISBN 13 : 9780128123515
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Englisch. N° de réf. du vendeur 9780128123515
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EUR 106
Expédition à EUR 23
Expédition depuis Allemagne vers Etats-Unis
Expédition depuis Allemagne vers Etats-Unis
Quantité disponible : 2 disponible(s)
Image d'archives
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Edité par
Elsevier Science Publishing Co Inc, 2018
ISBN 10 : 0128123516
ISBN 13 : 9780128123515
Ancien ou d'occasion
Paperback
Vendeur : World of Books Inc, Montgomery, IL, Etats-Unis
Évaluation du vendeur 4 sur 5 étoiles
Paperback. Etat : Very Good. Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. N° de réf. du vendeur CIN0128123516VG
Acheter D'occasion
EUR 129,98
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Expédition nationale : Etats-Unis
Expédition nationale : Etats-Unis
Quantité disponible : 1 disponible(s)
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Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Edité par
Elsevier Science & Technology, Academic Press, 2018
ISBN 10 : 0128123516
ISBN 13 : 9780128123515
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. N° de réf. du vendeur 9780128123515
Acheter neuf
EUR 122,02
Expédition à EUR 35
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Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Vendeur : preigu, Osnabrück, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Cell Surface GRP78, a New Paradigm in Signal Transduction Biology | Salvatore V. Pizzo | Taschenbuch | Englisch | Academic Press | EAN 9780128123515 | Verantwortliche Person für die EU: Elsevier B.V., Radarweg 29, 1043 NX AMSTERDAM, NIEDERLANDE, productsafety[at]elsevier[dot]com | Anbieter: preigu. N° de réf. du vendeur 126702389
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EUR 99,20
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