Articles liés à Osteoarthritis

9780192627353: Osteoarthritis

Synopsis

In recent years, a number of new developments have greatly enhanced our understanding of the aetiology, pathogenesis, and management of osteoarthritis. Understanding of the mechanism of cartilege breakdown has advanced, and new evidence from animal models has shown that the development and progression of osteoarthritis can be prevented or retarded pharmacologically. With more and more cases of this disease being seen each year, there are extensive research programmes underway to find effective treatments for this disease. Osteoarthritis brings together a team of experts on this prevalent disease to provide a comprehensive textbook examining all aspects of this increasingly common condition. Included among others are sections describing the pathogenesis of osteoarthritis, its clinical features, and the standard approaches to diagnosis. There are also sections covering, in depth, the management of OA, and the prospects for pharmacological treatments of joint breakdown in osteoarthritis. While being a valuable text for rheumatologists and orthopaedic surgeons, it should also be of interest to physical therapists, radiologists, pathologists, epidemiologists and general practitioners.

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Présentation de l'éditeur

At a time when prevalance of osteoarthritis (failure of the joint) is increasing with an aging population it is timely to review the latest evidence and management strategies for optimal treatment of patients with this, the most common joint disease of mankind. A number of exciting new developments related to etiopathogenesis and management make it highly desirable at this time to publish a fully comprehensive authorative discussion of the risk factors, mechanisms of joint damage, clinical aspects, differential diagnosis and treatment of OA. A review of the current understanding of the management of this disorder and of the basic mechanisms involved provides the rationale for publication of this new fully-updated edition. The book looks at the mechanisms for joint failure and how this may be due to abnormal cartilage or disease in underlying tissue. Significant coverage is given to exciting new evidence on disease-modifying drugs and methodologies for their outcomes evaluation. It is becoming increasingly recognised that optimal management of osteoarthritis requires a comprehensive program involving drugs and nonmedicinal components and, in some cases, surgery. Chapters on both non-surgical and surgical therapy are contained in the management section. The full coverage given in this book allows the physician to consider and choose the right blend of treatment for each patient from the range available whether physical, pharmacologic, surgical or supportive. The book is sympathetic to the significant differences that often exist between the perception of the patient and that of the physician regarding what's important in treatment and coverage is therefore given to the outcome measures needed for optimal evaluation of both. Highly illustrated in full colour throughout this difinative text is written principally for the clinical rheumatologists, although primary care physicians, orthopaedic surgeons, allied health professionals, basic researchers, members of the pharmaceutical industry who are involved in drug research and development, and regulatory staff also should find it useful.

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