The Synaptic Organization of the Brain - Couverture souple

Shepherd, Gordon M.

Couverture souple

ISBN 10 : 0195062566 ISBN 13 : 9780195062564

Editeur : Oxford University Press Inc, 1990

Synopsis

The third edition of The Synaptic Organization of the Brain continues the tradition of earlier editions in focusing on the principles underlying the organization of neurons and synapses into functional circuits within the best-studied regions of the brain: autonomic ganglia, spinal cord, olfactory bulb, retina, cerebellum, thalamus, basal ganglia, olfactory cortex, hippocampus, and neocortex. To ensure authoritative coverage, the chapters have been written by leading researchers in each region. As in past editions, each chapter follows the same format: neural elements, synaptic connections, basic circuits, physiological properties, neurotransmitters, and dendritic properties. Each chapter now has a concluding section which discusses functional implications. This organization gives a logical structure to the description of each region, and greatly facilitates comparisons between regions and identification of common principles. Highlights include the first comprehensive attempt to incorporate intrinsic excitable membrane properties into neural circuits throughout the brain, the latest experimental results from patch recordings, brain slices, and intracellular labelling, and 3-D reconstructions of neurons and connections. The book also provides up-to-date summaries of neurotransmitters, neuromodulators, second-messengers and ligand-and voltage-gated membrane channels for each brain region. Information on possible mechanisms underlying learning and memory in brain circuits is emphasized. A special focus is on methods for modeling neurons and circuits, as a first step toward a "biophysics of neural computation" and the construction of more realistic neural networks.

A propos du livre

Présentation de l'éditeur

It is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies os synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioural and gene-targeting methods. Leading experts in the best understood brain regions bring together the molecular, anatomical, functional, and behavioural data in authoritative integrated accounts. The chapters are organized in the same format, covering the neural elements, synaptic connections, basic circuits, physiology, neurotransmitters, neuromodulators, membrane properties, dendritic properties, and with a final section on how the circuits mediate specific behaviours. The uniform framework for each chapter enables the authors to higlight the principles that are common to all regions, as well as the adaptations unique to each, thus serving as a model for understanding the neural basis of behaviour.

Revue de presse

This fifth edition of Shepherd's well-respected text is still worth having on the bookshelf . . . the regions covered are dealt with systematically and clearly. Each chapter has a similar structure, with sections on the neuronal elements present, their synaptic connections and basic circuits, their intrinsic membrane properties, synaptic actions and dendritic properties, and the functional properties of the circuits. This is all done clearly and thoroughly, packing a great deal of information into a small space . . . The synaptic organisation of the brain is a classic text, and still very much worth having and reading for anyone interested in the details of neuroscience. (Physiology News, Number 56)

Détails de l'édition

• Éditeur: Oxford University Press Inc
• Date d'édition: 1990
• Langue: anglais
• ISBN 10: 0195062566
• ISBN 13: 9780195062564
• Reliure: Broché
• Numéro d'édition: 3
• Nombre de pages: 575
• Coordonnées du fabricant: Oxford University Press; https://corp.oup.com/; ; WMF Platz 1; Geislingen/Steige; Baden-W?rttemberg; 73312; Allemagne