Antisense Technology in the Central Nervous System - Couverture souple

Leslie, Ron A.

Couverture souple

ISBN 10 : 0198505388 ISBN 13 : 9780198505389

Editeur : Oxford University Press, 1999

Synopsis

Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of a certain protein, the method can in theory correct the problem. Although faster than transgenic techniques, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome. This is the first book to provide a critical review of the uses of this technology in the central nervous system. It includes: Background to the technology Problems of design and synthesis of antisense molecules Administration in the brain Protection of ODNs from metabolic destruction

Détails de l'édition

• Éditeur: Oxford University Press
• Date d'édition: 1999
• Langue: anglais
• ISBN 10: 0198505388
• ISBN 13: 9780198505389
• Reliure: Broché
• Nombre de pages: 270
• Coordonnées du fabricant: non disponible
• Personne responsable: Ufficio Anagrafiche Messaggerie; ufficio.anagrafiche@meli.it; ; Via Verdi, 8; Assago Milano; 20090; Italie