From DNA Damage and Stress Signalling to Cell Death: Poly Adp-Ribosylation Reactions - Couverture rigide

 
9780198506331: From DNA Damage and Stress Signalling to Cell Death: Poly Adp-Ribosylation Reactions
Couverture rigide
ISBN 10 : 0198506333 ISBN 13 : 9780198506331
Editeur : Oxford University Press, 2000

Synopsis

Over the last 10 years, it has become apparent that poly-ADP ribosylation reactions govern some of the fundamental processes of life. PARP 1 is a highly conserved enzyme and a constitutive factor of the DNA damage surveillance network and plays an essential role in the protection and processing of DNA ends as they arise in DNA damage, repair, and recombination. The recent discovery of multiple members of the PARP family suggests an expanded role for poly-ADP ribosylation reactions. Poly ADP-ribosylation Reactions contains basic knowledge of poly-ADP ribosylation reactions and reviews the most recent molecular (including the crystal structure) and genetic (including knock out mice) approaches that have contributed to our understanding of the physiological role PARP 1 and its homologues. A discussion of the novel pharmacological role of inhibition of PARP is also included. The final chapter outlines future directions in the field of cellular responses to DNA damage. Its comprehensive coverage of the multiple aspects of this type of post-translational modification induced by DNA damage mean this book will serve as reference for both new and experienced investigators.

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Présentation de l'éditeur

Over the last 10 years, it has become apparent that poly-ADP ribosylation reactions govern some of the fundamental processes of life. PARP 1 is a highly conserved enzyme and a constitutive factor of the DNA damage surveillance network and plays an essential role in the protection and processing of DNA ends as they arise in DNA damage, repair, and recombination. The recent discovery of multiple members of the PARP family suggests an expanded role for poly-ADP ribosylation reactions. Poly ADP-ribosylation Reactions contains basic knowledge of poly-ADP ribosylation reactions and reviews the most recent molecular (including the crystal structure) and genetic (including knock out mice) approaches that have contributed to our understanding of the physiological role PARP 1 and its homologues. A discussion of the novel pharmacological role of inhibition of PARP is also included. The final chapter outlines future directions in the field of cellular responses to DNA damage. Its comprehensive coverage of the multiple aspects of this type of post-translational modification induced by DNA damage mean this book will serve as reference for both new and experienced investigators.

Revue de presse

...well written and organized, and is equally useful for the experts and for scientists just entering this exciting and rapidly moving field. (Trends in Genetics)

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Éditeur
Oxford University Press
Date d'édition
2000
Langue
anglais
ISBN 10 
0198506333
ISBN 13 
9780198506331
Reliure
Relié
Nombre de pages
260
Éditeur
Murcia Gilbert De, Shall Sydney
Coordonnées du fabricant
non disponible
Personne responsable
Messaggerie Libri
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