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Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatmemt - Couverture rigide

 
9780198508786: Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatmemt
Couverture rigide
ISBN 10 : 0198508786 ISBN 13 : 9780198508786
Editeur : Oxford University Press, 2004

Synopsis

Details recent advances in the pathology of these diseases and implications for treatment

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Lysosomal storage diseases are inherited metabolic disorders characterized by severe pathology, typically involving the brain. Although individually rare, they collectively represent a significant group of diseases that primarily present in early infancy or childhood. In recent years considerable progress has been made in understanding the molecular mechanisms that lead to disordered function of the lysosomal system and to lysosomal storage. Unravelling the basis for these diseases is providing unique insight into the normal biology of cells and pointing the way to the development of therapeutic strategies for their treatment. Lysosomal Disorders of Brain details recent advances in the molecular and cellular pathologies of these diseases and in the development of effective therapies. After an overview of the biology of the endosomal-lysosomal system and the types of diseases resulting from defects in this system, the book describes in detail the molecular mechanisms of storage, model systems and pathophysiological mechanisms, and finally, new advances toward treatment. With each chapter written by leading experts in their field, this book will be valuable for scientists and clinicians in helping them understand the role of lysosomes in normal cells and mechanisms underlying these disorders, how they can be diagnosed, and the treatment options that are currently available.

Revue de presse

. . . this book is highly recommended . . for those readers wanting to get a clear and straightforward overview of LSDs . . . then this well-written book is a worthwhile investment. (Nature Cell Biology, Vol 6, Number 11)

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Éditeur
Oxford University Press
Date d'édition
2004
Langue
anglais
ISBN 10 
0198508786
ISBN 13 
9780198508786
Reliure
Relié
Nombre de pages
478
Éditeur
Platt Frances, Walkley Steven
Coordonnées du fabricant
Oxford University Press
https://corp.oup.com/

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