The Legacy of Cell Fusion - Couverture rigide

 
9780198547723: The Legacy of Cell Fusion
Couverture rigide
ISBN 10 : 0198547722 ISBN 13 : 9780198547723
Editeur : Oxford University Press, 1994

Synopsis

The powerful method of viral-induced fusion of animal cells was invented by Henry Harris and his colleagues in 1965, in order to study the genetics of somatic animal cells. This volume evaluates the impact of cell hybridization on the study of cell differentiation, gene mapping, gene regulation, and the development of monoclonal antibodies. Studies are presented on nuclear structure and function, intracellular transport, membrane protein mobility, and nuclear-cytoplasmic interactions in heterokaryons and other cells. Early experiements by Harris and co-workers suggested that gene loss plays an important role in tumour formation and that the malignant phenotype could be suppressed by hybridization with non-malignant cells. This principle has since been shown to apply to a wide range of natural and experimental tumours, in species ranging from Drosophila to man. Tumour-suppressor genes are discussed, together with the role of radiation-hybrid mapping in the analysis of genetic tumours. The volume concludes with an article in which Henry Harris sums up some of the unsolved questions that remain to be studied in the link between cell growth and differentiation. This volume aims to celebrate the legacy of cell fusion in its proper perspective.

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Présentation de l'éditeur

The powerful method of viral-induced fusion of animal cells was invented by Henry Harris and his colleagues in 1965, in order to study the genetics of somatic animal cells. This volume evaluates the impact of cell hybridization on the study of cell differentiation, gene mapping, gene regulation, and the development of monoclonal antibodies. Studies are presented on nuclear structure and function, intracellular transport, membrane protein mobility, and nuclear-cytoplasmic interactions in heterokaryons and other cells. Early experiements by Harris and co-workers suggested that gene loss plays an important role in tumour formation and that the malignant phenotype could be suppressed by hybridization with non-malignant cells. This principle has since been shown to apply to a wide range of natural and experimental tumours, in species ranging from Drosophila to man. Tumour-suppressor genes are discussed, together with the role of radiation-hybrid mapping in the analysis of genetic tumours. The volume concludes with an article in which Henry Harris sums up some of the unsolved questions that remain to be studied in the link between cell growth and differentiation. This volume aims to celebrate the legacy of cell fusion in its proper perspective.

Revue de presse

Plan to enjoy this book. (Paul L. McNeil, College of Georgia, Trends in Cell Biology, Vol. 5, June 1995)

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Oxford University Press
Date d'édition
1994
Langue
anglais
ISBN 10 
0198547722
ISBN 13 
9780198547723
Reliure
Relié
Nombre de pages
320
Éditeur
Gordon Siamon
Coordonnées du fabricant
non disponible
Personne responsable
Ufficio Anagrafiche Messaggerie
ufficio.anagrafiche@meli.it

Via Verdi, 8
Assago Milano
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Italie