Articles liés à An Introduction to Medicinal Chemistry
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Synopsis
This illustrated text provides undergraduate and postgraduate students with an accessible introduction to medicinal chemistry. It covers basic principles and background, and then describes the general tactics and strategies employed in developing an effective drug. Through the use of numerous examples, it highlights both the difficulties faced by the medicinal chemist and the great power and potential of rational drug design. This book is suitable for undergraduates on courses in chemistry (2nd and 3rd year) and medicinal chemistry (1st and 2nd year), and postgraduate chemists beginning work in pharmaceutical research.
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Présentation de l'éditeur
For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market? An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development. The Online Resource Centre features: For students: · Multiple Choice Questions to support self-directed learning · Web articles describing recent developments in the field and further information on topics covered in the book · Journal Club to encourage students to critically analyse the research literature · Molecular Modelling Exercises, with new exercises in Chem3D · New assignments to help students develop data analysis and problem solving skills For registered adopters of the book: · A test bank of additional multiple-choice questions, with links to relevant sections in the book · Answers to end-of-chapter questions. · Figures from the book, ready to download. · Power Point slides to accompany every chapter in the book.
Présentation de l'éditeur
The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is very accessible to students. Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to specific drugs from HIV inhibitors to painkillers. The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical issues and most frequently used techniques. An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses. With enhanced attention to the pedagogical details such as key points and boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading. Online Resource Centre The Online Resource Centre features: For registered adoptors of the book: · Answers to end-of-chapter questions · Figures from the book · Power Point slides · Test Bank questions For students: · Hyperlinked bibliography · Six-monthly updates to text · 3D Rotatable structures
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